Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells

Table 1 Percentage of cells displaying increased forward scatter and side scatter light dispersion properties

% of cells with increased FSC and SSC	MNC + PHA	MNC + PHA + BM-MSCs	MNC + PHA + UCM-MSCs	MNC + PHA + AT-MSCs
% of cells with increased FSC and SSC	n = 17	n = 5	n = 7	n = 5
Total mononuclear cells	51 ± 3	31 ± 4^{a; d}	41 ± 15^d	21 ± 10^{a; c; d}
Total T cells	56 ± 2	31 ± 6^{a; d}	47 ± 19^d	19 ± 13^{a; c; d}
CD4⁺ T cells	54 ± 4	26 ± 3^{a; d}	47 ± 22^d	15 ± 11^{a; c; d}
CD8⁺ T cells	59 ± 4	38 ± 11^{a; d}	49 ± 16^d	21 ± 7^{a; b; c; d}
B cells	18 ± 3	9 ± 1^a	18 ± 9^b	7 ± 4^{a; c; d}

Percentage (mean ± standard deviation) of cells with increased forward scatter and side scatter light dispersion characteristics after PHA stimulation, in the absence or in the presence of MSCs from different sources, within the total MNC in culture and within the following cell populations: total T cells, CD4⁺ T cells, CD8⁺ T cells and B cells.
Results are expressed as mean percentage ± standard deviation. Statistically significant differences were considered when P <0,05 for Mann–Whitney test:^acomparing with MNC + PHA; ^bcomparing with MNC + PHA + BM-MSCs; ^ccomparing with MNC + PHA + UCM-MSCs. Statistically significant differences were considered when P <0,05 for Wilcoxon paired-sample test: ^dcomparing with MNC + PHA.
AT, adipose tissue; BM, bone marrow; MNC, mononuclear cells; MSCs, mesenchymal stem cells PHA, phytohemagglutinin; UCM, umbilical cord matrix.

ISSN: 1757-6512