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Figure 2 | Stem Cell Research & Therapy

Figure 2

From: Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells – a rheumatoid arthritis mouse model

Figure 2

In vitro dose response. A) T2eff map for 1, 5 and 10 μg/ml SiMAG-labelled cells ranging in cell doses (103, 104, 105, 3 × 105, 5 × 105). B) Bar chart depicting i) T2 and ii) normalised T1 measurements at each particle concentration (1 to 10 μg/ml) and cell dose (103, 104, 105, 3 × 105, 5×105). Red line indicates MRI visibility threshold implying that any cell: particle combination resulting in a T2 less than 0.084 ms can be detected by MRI. C) Plot to show correlation between number of cells and i) T2eff and ii) normalised T1 for three different concentrations (1, 5 and 10 μg/ml) of SiMAG. Data = average ± SD (n = 6). Assume *** significant levels unless otherwise stated (P <0.005). *Indicates significant statistical difference in T2 between 500,000 cells labelled with either 5 μg/ml or 10 μg/ml (P <0.01). MRI, magnetic resonance imaging; T1, longitudinal relaxation time; T2, transverse relaxation time; T2eff, effective transverse relaxation time.

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