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Table 1 Cellular markers that may contribute to lung cancer stem cell properties

From: Lung cancer stem cells and low-intensity laser irradiation: a potential future therapy?

Marker Name Cellular function Ligand Cancer stem cell
  Lung Other
CD44 Pgp-1 Hyaluronic acid receptor Hyaluronic acid and hyaluronate-interacting growth factors, osteopontin NSCLC Hematopoietic, breast
CD133 Prominin-1 Modulator of intracellular accumulation of exogenous compounds (transferin-CD133-iron network) cell metabolism [29] Neurotrophic receptor RET tyrosine kinase expression [30] No natural ligand identified [31] NSCLC [32] Brain, colon, pancreas
CD117 Stem cell factor receptor Growth factor receptor Stem cell factor SCLC [33] Hematopoietic
CD87 Urokinase plasminogen activator uPA receptor uPA NSCLC/SCLC [34] Unknown
SP Side population Drug resistance EGFR [35] TRAIL [36] SC/NSCLC Hematopoietic, brain, breast
ALDH Aldehyde dehydrogenase Alcohol metabolism Acetaldehyde NSCLC [37] Hematopoietic, breast, prostate
  1. EGFR epidermal growth factor receptor, NSCLC non-small cell lung cancer, SC stem cell, SCLC small cell lung cancer, TRAIL tumor necrosis factor-related apoptosis-inducing ligand, uPA urokinase plasminogen activator. Modified from [19].