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Table 2 Flow cytometry results of low- and high-passaged umbilical cord mesenchymal stem cells (UC MSCs)

From: Transplantation of umbilical cord-derived mesenchymal stem cells into the striata of R6/2 mice: behavioral and neuropathological analysis

 

Passage 5

Passage 45

CD45

20.5

1.7

SCA1

26.9

30.1

SSEA4

10.9

55.4

MHC Class I

2.9

1.8

MHC Class II

10.8

1.5

  1. The number of cells positively expressing SCA1 remained relatively stable as passage number increased. A decrease in the hematopoietic stem cell marker CD45 was observed as cell passage increased. Also, an increase of expression of the stem cell marker SSEA4 between low- and high-passaged cells occurred. Expression of MHC Class I remained relatively stable between low- and high-passaged cells, but a decrease in MHC Class II was observed between low- and high-passaged cells, respectively. MHC, major histological complex; SSEA4, stage specific embryonic antigen 4.
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Stem Cell Research & Therapy

ISSN: 1757-6512