Figure 5

Comparison of alcohol consumption before and after transplantation. (a) Consumption of 10% ethanol was lower after transplantation in mice transplanted with C17.hDAT cells when compared with mice receiving C17.mock cells. While average pre- versus posttransplant consumption was reduced in most of the C17.hDAT animals, it remained unchanged or slightly elevated in saline control and C17.mock groups, respectively. *P < 0.05 comparing posttransplant C17.hDAT with posttransplant C17.mock group. (b) Average consumption of 10% alcohol before and after transplantation in individual animals. The effects on consumption between pre and post measurements are depicted by different line colors: red (reduction in consumption), black lines (increase), and blue (no change). Mean group value is represented by a green horizontal bar for each group. Although five of nine C17.hDAT animals reduced their consumption, only two of eight C17.mock animals did. Pre, before transplantation; post, after transplantation.