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Table 1 The U18: 2-year funded National Institutes of Health Microphysiological Systems Program investigators

From: The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline

Primary U18 investigator

Institution

Title

James M Wells, PhD

Cincinnati Children's Hospital Medical Center, OH

Generating human intestinal organoids with an enteric nervous system

Angela Christiano, PhD

Columbia University Health Sciences, New York City, NY

Modeling complex disease using induced pluripotent stem cell-derived skin constructs

Mark Donowitz, MD

Johns Hopkins University, Baltimore, MD

Human intestinal organoids: preclinical models of noninflammatory diarrhea

Thomas Hartung, MD, PhD

Johns Hopkins University, Baltimore, MD

Three-dimensional model of human brain development for studying gene/environment interactions

John P Lynch, MD, PhD

University of Pennsylvania, Philadelphia, PA

Modeling oxidative stress and DNA damage using a gastrointestinal organotypic culture system

Rocky S Tuan, PhD

University of Pittsburgh, PA

Three-dimensional osteochondral micro-tissue to model pathogenesis of osteoarthritis

Joan E Nichols, PhD

The University of Texas Medical Branch at Galveston, TX

Three-dimensional human lung model to study lung disease and formation of fibrosis

  1. The emphasis of these 2-year grants is the incorporation of human embryonic, induced pluripotent stem cell and progenitor cell sources into organ-specific microphysiological systems. The multicellular models developed will represent the three-dimensional architecture and cellular composition of the organ being modeled, and will lead to the development of microphysiological systems that represent the function of the target organ under normal physiological conditions and disease states.