Figure 1
From: Building a microphysiological skin model from induced pluripotent stem cells
Schematic diagram of generating induced pluripotent stem cells to create three-dimensional skin equivalents for drug testing. Human somatic cells such as skin fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSCs), from which various cell types (including fibroblasts and keratinocytes) can be differentiated. Subsequently, the iPSC-derived cells can be combined with collagen to reconstitute three-dimensional (3D) skin constructs for drug testing.