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Figure 1 | Stem Cell Research & Therapy

Figure 1

From: Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems

Figure 1

Modeling inflammation in the esophagus. (a) Diagram illustrating how activated immune cells produce significant amounts of reactive oxygen species (ROS), resulting in increased oxidative stress and DNA damage, which in turn disrupts the integrity of the epithelium, leading to apoptosis, and contributing to the evolution of diseases including Barrett's esophagus (BE) and cancer. (b), (c) Histological analysis of esophageal keratinocytes grown under organotypic conditions in the presence of active immune cells.

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