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Figure 1 | Stem Cell Research & Therapy

Figure 1

From: An integrated in vitro model of perfused tumor and cardiac tissue

Figure 1

The project will create three separate microphysiological systems that can then be incorporated. Three separate microphysiological systems will simulate: (a) a perfused network of human capillaries derived from human induced pluripotent stem cells in a porcine cardiac extracellular matrix, (b) a network of human capillaries in a the presence of cardiac muscle spheroids derived from the human induced pluripotent stem cells, and (c) a network of human capillaries in the presence of solid tumor spheroids. As depicted, the arteriole and venule are microfluidic channels of high pressure/high oxygen and low pressure/low oxygen, respectively. (d) Any of these individual microphysiological systems can be incorporated into a modular high-throughput platform that includes a row of perfused microphysiological systems (perfused tumor spheroids shown as an example). The platform can include modular connectors to facilitate addition of other organ systems. (e) The final phase is to combine the individual microphysiological systems into a single integrated system of perfused tumor spheroid and cardiac muscle. SC, stromal cells; PC, pericyte-like cell; TS, tumor spheroid; CS, cardiomyocyte spheroid.

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