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Table 1 Ongoing clinical trials on stem cell therapy for treatment of acute myocardial infarction and heart failure (Clinicaltrials.gov)

From: Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?

Trial name (reference)

Cell type

Source

Route of delivery

Endpoint

Phase of trial

Number of patients

Disease status

Study identifier

Trial title

MARVEL/Warren et al.

Skeletal myoblasts

Autologous

Intramyocardial

Safety/efficacy

Phase I and II

170

Ischemic cardiomyopathy

NCT00526253

To Assess Safety and Efficacy of Myoblast Implantation Into Myocardium Post Myocardial Infarction

MYSTAR-5-YEAR/Mariann et al.

BM mononuclear cells

Autologous

Intramyocardial and intracoronary

Safety/efficacy

Phase I and II

60

Ischemic cardiomyopathy

NCT01395212

Long-term Follow-up of Patients With Ischemic Heart Disease Treated With Stem Cell Therapy

COAT/Sandeep et al.

BM mononuclear cells

Autologous

Intracoronary

Safety/efficacy

Phase I and II

40

Ischemic cardiomyopathy

NCT01625949

Stem Cell Therapy in Patients With Myocardial Infarction and Persistent Total Occlusion of Infarct Related Artery

AMIRST/Ashok et al.

BM mononuclear cells

Autologous

Intracoronary

Safety/efficacy

Phase I and II

30

Acute MI

NCT01536106

Rapid Delivery of Autologous Bone Marrow Derived Stem Cells in Acute Myocardial Infarction Patients

BAMI/Anthony et al.

BM mononuclear cells

Autologous

Intracoronary

Safety/efficacy

Phase III

3,000

Acute MI

NCT01569178

The Effect of Intracoronary Reinfusion of Bone Marrow-derived Mononuclear Cells (BM-MNC) on All Cause Mortality in Acute Myocardial Infarction

AMR-1/Arshed et al.

BM CD34+

Autologous

Intracoronary

Safety/efficacy

Phase I and II

40

Acute MI

NCT00313339

Intra-coronary Infusion of Bone Marrow Derived Autologous CD34+ Selected Cells in Patients With Acute Myocardial Infarction

PreSERVE-AMI/ Arshed et al.

BM CD34+

Autologous

Intracoronary

Safety/efficacy

Phase I and II

160

Ischemic cardiomyopathy

NCT01495364

AMR-001 Versus Placebo Post ST Segment Elevation Myocardial Infarction

NOGA-DCM/Vrtovec et al.

BM CD34+

Autologous

Intramyocardial versus intracoronary

Safety/efficacy

Phase I and II

90

Dilated cardiomyopathy

NCT01350310

Safety and Efficacy Study of Intramyocardial Stem Cell Therapy in Patients With Dilated Cardiomyopathy

IMPACT-CABG/ Nicolas et al.

BM CD133+

Autologous

Intramyocardial

Safety/efficacy

Phase I and II

20

Ischemic cardiomyopathy

NCT01033617

IMPlantation of Autologous CD133+ sTem Cells in Patients Undergoing CABG

PERFECT/Gustav et al.

BM CD133+

Autologous

Intramyocardial

Efficacy

Phase II

142

Ischemic cardiomyopathy

NCT00950274

Intramyocardial Transplantation of Bone Marrow Stem Cells in Addition to Coronary Artery Bypass Graft (CABG) Surgery

SELECT-AMI/Jozef et al.

BM CD133+

Autologous

Intracoronary

Safety/efficacy

Phase I and II

60

Acute MI

NCT00529932

A Trial Using CD133 Enriched Bone Marrow Cells Following Primary Angioplasty for Acute Myocardial Infarction

AlsterMACS

BM CD133+

Autologous

Intramyocardial versus intracoronary

Safety/efficacy

Phase I and II

64

Ischemic cardiomyopathy

NCT01337011

Intra-coronary Versus Intramyocardial Application of Enriched CD133pos Autologous Bone Marrow Derived Stem Cells

ENACT-AMI/ Duncan et al.

Endothelial progenitor cells

Autologous

Intracoronary

Efficacy

Phase II

100

Acute MI

NCT00936819

Enhanced Angiogenic Cell Therapy - Acute Myocardial Infarction Trial

REPAIR-ACS/Andreas et al.

BM derived progenitor cells

Autologous

Intracoronary

Efficacy

Phase II

100

Acute MI

NCT00711542

Effects of Intracoronary Progenitor Cell Therapy on Coronary Flow Reserve After Acute MI

ESTIMATION/Evgeny et al.

BM MSCs

Autologous

Intramyocardial

Efficacy

Phase II

50

Acute MI

NCT01394432

Study for Endocardial Mesenchymal Stem Cells Implantation in Patients After Acute Myocardial Infarction

Kastrup et al.

BM MSCs

Autologous

Intramyocardial

Efficacy

Phase II

60

Ischemic cardiomyopathy

NCT00644410

Autologous Mesenchymal Stromal Cell Therapy in Heart Failure

Maskon et al.

BM MSCs

Autologous

Intracoronary

Safety/efficacy

Phase I and II

80

Ischemic cardiomyopathy

NCT01720888

Intracoronary Autologous Mesenchymal Stem Cells Implantation in Patients With Ischemic Dilated Cardiomyopathy

RELIEF/Yang et al.

BM MSCs

Autologous

Intracoronary

Safety/efficacy

Phase I and II

135

Acute MI

NCT01652209

A Randomized, Open labEled, muLticenter Trial for Safety and Efficacy of Intracoronary Adult Human Mesenchymal stEm Cells Acute Myocardial inFarction

MESAMI/ Jerome et al.

BM MSCs

Autologous

Intramyocardial

Safety

Phase I

10

Ischemic cardiomyopathy

NCT01076920

Mesenchymal Stem Cells and Myocardial Ischemia

PoseidonDCM/Joshua et al.

BM MSCs

Allogeneic versus autologous

Intramyocardial

Safety/efficacy

Phase I and II

36

Dilated cardiomyopathy

NCT01392625

PercutaneOus StEm Cell Injection Delivery Effects On Neomyogenesis in Dilated CardioMyopathy

Perin et al.

Mesenchymal precursor cells

Allogeneic

Intramyocardial

Safety/efficacy

Phase I and II

25

Ischemic cardiomyopathy

NCT00555828

Safety Study of Allogeneic Mesenchymal Precursor Cells (MPCs) in Subjects With Recent Acute Myocardial Infarction

AMICI/ Eric et al.

Mesenchymal precursor cells

Allogeneic

Intracoronary

Safety/efficacy

Phase I and II

225

Acute MI

NCT01781390

Safety Study of Allogeneic Mesenchymal Precursor Cell Infusion in MyoCardial Infarction

MyStromalCell/Kastrup et al.

Adipose MSCs

Autologous

Intramyocardial

Efficacy

Phase II

60

Ischemic cardiomyopathy

NCT01449032

MesenchYmal STROMAL CELL Therapy in Patients With Chronic Myocardial Ischemia

ATHENA/Perin et al.

Adipose MSCs

Autologous

Intramyocardial

Safety/efficacy

Phase I and II

45

Ischemic cardiomyopathy

NCT01556022

Safety and Feasibility Trial of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia

PRECISE/Fernández-Avilés et al.

Adipose MSCs

Autologous

Intramyocardial

Safety/efficacy

Phase I and II

36

Ischemic cardiomyopathy

NCT00426868

A Randomized Clinical Trial of adiPose-deRived stEm and Regenerative Cells In the Treatment of Patients With Non revaScularizable ischEmic Myocardium

APOLLO/Serruys et al.

Adipose MSCs

Autologous

Intramyocardial

Safety/efficacy

Phase I and II

48

Acute MI

NCT00442806

A Randomized Clinical Trial of AdiPOse-derived Stem ceLLs in the Treatment of Patients With ST-elevation myOcardial Infarction

RIMECARD

Umbilical cord MSCs

Allogeneic

Intravenous

Safety/efficacy

Phase I and II

30

Ischemic cardiomyopathy

NCT01739777

Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy

CHART-1/Terzic et al.

BM MSC cardiopoietic cells

Autologous

Intramyocardial

Safety/efficacy

Phase I and II

240

Ischemic cardiomyopathy

NCT01768702

Safety and Efficacy of Autologous Cardiopoietic Cells for Treatment of Ischemic Heart Failure

RECONSTRUCT/Marban et al.

Cardiosphere-derived cells

Autologous

Intramyocardial

Safety/efficacy

Phase I and II

24

Ischemic cardiomyopathy

NCT01496209

REgenerative CardiOsphere iNjection to STRengthen dysfUnCTional Hearts

ALLSTAR/Smith et al.

Cardiosphere-derived cells

Allogeneic

Intracoronary

Safety/efficacy

Phase I and II

274

Ischemic cardiomyopathy

NCT01458405

Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration

Gourabi et al.

Cardiac stem cells

Autologous

Intracoronary

Safety/efficacy

Phase I and II

50

Ischemic cardiomyopathy

NCT01758406

Transplantation of Autologous Cardiac Stem Cells in Ischemic Heart Failure

MESS/Mariann et al.

Cardiac stem cells

Autologous

Intracoronary

Safety/efficacy

Phase III

1,000

Ischemic cardiomyopathy

NCT01098591

Meta-analysis of Cardiac Stem Cell Studies

  1. BM, bone marrow; MI, myocardial infarction; MSC, mesenchymal stem cell.