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Table 1 Ongoing clinical trials on stem cell therapy for treatment of acute myocardial infarction and heart failure (Clinicaltrials.gov)

From: Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?

Trial name (reference) Cell type Source Route of delivery Endpoint Phase of trial Number of patients Disease status Study identifier Trial title
MARVEL/Warren et al. Skeletal myoblasts Autologous Intramyocardial Safety/efficacy Phase I and II 170 Ischemic cardiomyopathy NCT00526253 To Assess Safety and Efficacy of Myoblast Implantation Into Myocardium Post Myocardial Infarction
MYSTAR-5-YEAR/Mariann et al. BM mononuclear cells Autologous Intramyocardial and intracoronary Safety/efficacy Phase I and II 60 Ischemic cardiomyopathy NCT01395212 Long-term Follow-up of Patients With Ischemic Heart Disease Treated With Stem Cell Therapy
COAT/Sandeep et al. BM mononuclear cells Autologous Intracoronary Safety/efficacy Phase I and II 40 Ischemic cardiomyopathy NCT01625949 Stem Cell Therapy in Patients With Myocardial Infarction and Persistent Total Occlusion of Infarct Related Artery
AMIRST/Ashok et al. BM mononuclear cells Autologous Intracoronary Safety/efficacy Phase I and II 30 Acute MI NCT01536106 Rapid Delivery of Autologous Bone Marrow Derived Stem Cells in Acute Myocardial Infarction Patients
BAMI/Anthony et al. BM mononuclear cells Autologous Intracoronary Safety/efficacy Phase III 3,000 Acute MI NCT01569178 The Effect of Intracoronary Reinfusion of Bone Marrow-derived Mononuclear Cells (BM-MNC) on All Cause Mortality in Acute Myocardial Infarction
AMR-1/Arshed et al. BM CD34+ Autologous Intracoronary Safety/efficacy Phase I and II 40 Acute MI NCT00313339 Intra-coronary Infusion of Bone Marrow Derived Autologous CD34+ Selected Cells in Patients With Acute Myocardial Infarction
PreSERVE-AMI/ Arshed et al. BM CD34+ Autologous Intracoronary Safety/efficacy Phase I and II 160 Ischemic cardiomyopathy NCT01495364 AMR-001 Versus Placebo Post ST Segment Elevation Myocardial Infarction
NOGA-DCM/Vrtovec et al. BM CD34+ Autologous Intramyocardial versus intracoronary Safety/efficacy Phase I and II 90 Dilated cardiomyopathy NCT01350310 Safety and Efficacy Study of Intramyocardial Stem Cell Therapy in Patients With Dilated Cardiomyopathy
IMPACT-CABG/ Nicolas et al. BM CD133+ Autologous Intramyocardial Safety/efficacy Phase I and II 20 Ischemic cardiomyopathy NCT01033617 IMPlantation of Autologous CD133+ sTem Cells in Patients Undergoing CABG
PERFECT/Gustav et al. BM CD133+ Autologous Intramyocardial Efficacy Phase II 142 Ischemic cardiomyopathy NCT00950274 Intramyocardial Transplantation of Bone Marrow Stem Cells in Addition to Coronary Artery Bypass Graft (CABG) Surgery
SELECT-AMI/Jozef et al. BM CD133+ Autologous Intracoronary Safety/efficacy Phase I and II 60 Acute MI NCT00529932 A Trial Using CD133 Enriched Bone Marrow Cells Following Primary Angioplasty for Acute Myocardial Infarction
AlsterMACS BM CD133+ Autologous Intramyocardial versus intracoronary Safety/efficacy Phase I and II 64 Ischemic cardiomyopathy NCT01337011 Intra-coronary Versus Intramyocardial Application of Enriched CD133pos Autologous Bone Marrow Derived Stem Cells
ENACT-AMI/ Duncan et al. Endothelial progenitor cells Autologous Intracoronary Efficacy Phase II 100 Acute MI NCT00936819 Enhanced Angiogenic Cell Therapy - Acute Myocardial Infarction Trial
REPAIR-ACS/Andreas et al. BM derived progenitor cells Autologous Intracoronary Efficacy Phase II 100 Acute MI NCT00711542 Effects of Intracoronary Progenitor Cell Therapy on Coronary Flow Reserve After Acute MI
ESTIMATION/Evgeny et al. BM MSCs Autologous Intramyocardial Efficacy Phase II 50 Acute MI NCT01394432 Study for Endocardial Mesenchymal Stem Cells Implantation in Patients After Acute Myocardial Infarction
Kastrup et al. BM MSCs Autologous Intramyocardial Efficacy Phase II 60 Ischemic cardiomyopathy NCT00644410 Autologous Mesenchymal Stromal Cell Therapy in Heart Failure
Maskon et al. BM MSCs Autologous Intracoronary Safety/efficacy Phase I and II 80 Ischemic cardiomyopathy NCT01720888 Intracoronary Autologous Mesenchymal Stem Cells Implantation in Patients With Ischemic Dilated Cardiomyopathy
RELIEF/Yang et al. BM MSCs Autologous Intracoronary Safety/efficacy Phase I and II 135 Acute MI NCT01652209 A Randomized, Open labEled, muLticenter Trial for Safety and Efficacy of Intracoronary Adult Human Mesenchymal stEm Cells Acute Myocardial inFarction
MESAMI/ Jerome et al. BM MSCs Autologous Intramyocardial Safety Phase I 10 Ischemic cardiomyopathy NCT01076920 Mesenchymal Stem Cells and Myocardial Ischemia
PoseidonDCM/Joshua et al. BM MSCs Allogeneic versus autologous Intramyocardial Safety/efficacy Phase I and II 36 Dilated cardiomyopathy NCT01392625 PercutaneOus StEm Cell Injection Delivery Effects On Neomyogenesis in Dilated CardioMyopathy
Perin et al. Mesenchymal precursor cells Allogeneic Intramyocardial Safety/efficacy Phase I and II 25 Ischemic cardiomyopathy NCT00555828 Safety Study of Allogeneic Mesenchymal Precursor Cells (MPCs) in Subjects With Recent Acute Myocardial Infarction
AMICI/ Eric et al. Mesenchymal precursor cells Allogeneic Intracoronary Safety/efficacy Phase I and II 225 Acute MI NCT01781390 Safety Study of Allogeneic Mesenchymal Precursor Cell Infusion in MyoCardial Infarction
MyStromalCell/Kastrup et al. Adipose MSCs Autologous Intramyocardial Efficacy Phase II 60 Ischemic cardiomyopathy NCT01449032 MesenchYmal STROMAL CELL Therapy in Patients With Chronic Myocardial Ischemia
ATHENA/Perin et al. Adipose MSCs Autologous Intramyocardial Safety/efficacy Phase I and II 45 Ischemic cardiomyopathy NCT01556022 Safety and Feasibility Trial of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia
PRECISE/Fernández-Avilés et al. Adipose MSCs Autologous Intramyocardial Safety/efficacy Phase I and II 36 Ischemic cardiomyopathy NCT00426868 A Randomized Clinical Trial of adiPose-deRived stEm and Regenerative Cells In the Treatment of Patients With Non revaScularizable ischEmic Myocardium
APOLLO/Serruys et al. Adipose MSCs Autologous Intramyocardial Safety/efficacy Phase I and II 48 Acute MI NCT00442806 A Randomized Clinical Trial of AdiPOse-derived Stem ceLLs in the Treatment of Patients With ST-elevation myOcardial Infarction
RIMECARD Umbilical cord MSCs Allogeneic Intravenous Safety/efficacy Phase I and II 30 Ischemic cardiomyopathy NCT01739777 Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy
CHART-1/Terzic et al. BM MSC cardiopoietic cells Autologous Intramyocardial Safety/efficacy Phase I and II 240 Ischemic cardiomyopathy NCT01768702 Safety and Efficacy of Autologous Cardiopoietic Cells for Treatment of Ischemic Heart Failure
RECONSTRUCT/Marban et al. Cardiosphere-derived cells Autologous Intramyocardial Safety/efficacy Phase I and II 24 Ischemic cardiomyopathy NCT01496209 REgenerative CardiOsphere iNjection to STRengthen dysfUnCTional Hearts
ALLSTAR/Smith et al. Cardiosphere-derived cells Allogeneic Intracoronary Safety/efficacy Phase I and II 274 Ischemic cardiomyopathy NCT01458405 Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration
Gourabi et al. Cardiac stem cells Autologous Intracoronary Safety/efficacy Phase I and II 50 Ischemic cardiomyopathy NCT01758406 Transplantation of Autologous Cardiac Stem Cells in Ischemic Heart Failure
MESS/Mariann et al. Cardiac stem cells Autologous Intracoronary Safety/efficacy Phase III 1,000 Ischemic cardiomyopathy NCT01098591 Meta-analysis of Cardiac Stem Cell Studies
  1. BM, bone marrow; MI, myocardial infarction; MSC, mesenchymal stem cell.