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Figure 11 | Stem Cell Research & Therapy

Figure 11

From: Apoptotic adipose-derived mesenchymal stem cell therapy protects against lung and kidney injury in sepsis syndrome caused by cecal ligation puncture in rats

Figure 11

Histopathological changes and inflammatory cell infiltration in lung parenchyma at 72 hours after the CLP procedure. A to D) Microscopic findings of H & E stain (100x) of lung parencyma at 72 hours after the procedure. Scale bars in the right lower corners represent 100 μm. E) Quantitative analysis of the number of alveolar sacs. * versus other groups with different symbols (*, †, ‡, §), P <0.0001. F) Quantitative analysis of crowded score. * versus other groups with different symbols (*, †, ‡, §), P <0.001. G to J) Immunohistochemical stain (200x) for CD3+ cells in lung parencyma at 72 hours after the procedure. Scale bars in right lower corners represent 50 μm. K) Quantitative analysis of CD3+ cells. * versus other groups with different symbols (*, †, ‡, §), P <0.0001. All statistical analyses using one-way ANOVA, followed by the Bonferroni multiple comparison post hoc test (n = 8). Symbols (*, †, ‡, §) indicate significance (at 0.05 level). SC, sham control; CLP, cecal ligation and puncture; H-ADMSC, healthy adipose-derived mesenchymal stem cell; A-ADMSC, apoptotic adipose-derived mesenchymal stem cell. ANOVA, analysis of variance.

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