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Figure 13 | Stem Cell Research & Therapy

Figure 13

From: Apoptotic adipose-derived mesenchymal stem cell therapy protects against lung and kidney injury in sepsis syndrome caused by cecal ligation puncture in rats

Figure 13

Histopathological changes in lung and kidney at 72 hours after the CLP procedure with one dose of ADMSC treatment. A to D) Microscopic findings of H & E stain (100x) of lung parenchyma at 72 hours after the procedure. Scale bars in the right lower corners represent 100 μm. E) Quantitative analysis of the number of alveolar sacs. * versus other groups with different symbols (*, †, ‡, §), P <0.001. F) Quantitative analysis of crowded score. * versus other groups with different symbols (*, †, ‡, §), P <0.001. G to J) H & E stain (200x) showing the pathological findings in kidney at 72 hours after the CLP procedure. Scale bars in the right lower corners represent 50 μm. yellow arrows = loss of brush border in renal tubules; blue arrows = dilatation of Bowman’s capsule. K) * versus other groups with different symbols (*, †, ‡, §), P <0.001. All statistical analyses using one-way ANOVA, followed by the Bonferroni multiple comparison post hoc test (n = 6). Symbols (*, †, ‡, §) indicate significance (at 0.05 level). SC, sham control; CLP, cecal ligation and puncture; H-ADMSC, healthy adipose-derived mesenchymal stem cell; A-ADMSC ,apoptotic adipose-derived mesenchymal stem cell. ANOVA, analysis of variance.

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