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Table 1 Stereological analysis of wounds in diabetic animals

From: Autologous circulating angiogenic cells treated with osteopontin and delivered via a collagen scaffold enhance wound healing in the alloxan-induced diabetic rabbit ear ulcer model

Parameter

CACs (OPN) + Collagen

CACs + Collagen

Collagen

Untreated

Wound volume (mm3)

13.2 ± 5.1*

14.1 ± 3.5

17.4 ± 3.6#*

12.03 ± 3.69

Total volume of inflammatory cells (mm3)

2.37 ± 0.97#

3.01 ± 1.16#

3.21 ± 0.91#

1.39 ± 0.5

Surface density of blood vessels in wound (mm-1)

22.4 ± 9.3#

21.6 ± 4.34#

25.6 ± 5.8#

11.1 ± 5

Surface area of blood vessels (mm2)

306.3 ± 178

330.5 ± 20#

442 ± 112#

146 ± 116

Length density of blood vessels in wound (mm-2)

6,212 ± 1,424#

6,534 ± 1,589#

7,575 ± 1,610#

4,116 ± 1093

Total length of blood vessels in wound (mm)

81,678 ± 35,117

90,490 ± 26,997#

131,220 ± 34,187#

49,337 ± 51595

Radial diffusion distance (μm)

7.29 ± 0.9#

7.16 ± 0.1#

6.56 ± 0.6#

9.05 ± 0.15

Vessel diameter (μm)

1.8 ± 0.47#

1.76 ± 0.46

1.74 ± 0.3

1.35 ± 0.38

  1. Stereology analyzed by ANOVA followed by Fisher’s pairwise comparison, mean ± standard deviation, n = 8, *P <0.05 compared to * in the same row, #P <0.05 compared to untreated wound.