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Figure 3 | Stem Cell Research & Therapy

Figure 3

From: Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapoptotic, and endogenous cell-activation mechanisms

Figure 3

Paracrine effect of UCX® in in vitro vasculogenesis by HUVECs. Matrigel assay was performed by seeding HUVECs in EBM-2 supplemented with BM (A), CMN (B) or CMH (C) for 3,5 hours. Cells seeded in UCX®-conditioned media formed more capillary-like structures (D, by 42.7% ± 5.6% in CMN and 53.1% ± 4.7% in CMH) and branching points (E, by 35.8% ± 5.6% in CMN and 47.4% ± 4.3% in CMH), suggesting a pro-angiogenic effect. The tubes formed in CMN- or CMH-supplemented media were longer (F, by 35.8% ± 3.2% in CMN and 55.5% ± 3.7% in CMH) and thicker (G, by 81.4% ± 6.8% in CMN and 94.8% ± 8.8% in CMH), in comparison to those formed in BM, further corroborating the observed in vivo vasculogenic effect. ***P < 0.0001.

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