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Figure 4 | Stem Cell Research & Therapy

Figure 4

From: Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapoptotic, and endogenous cell-activation mechanisms

Figure 4

Paracrine effect of UCX® in hypoxia-induced apoptosis of HL-1 cardiomyocytes. (A through E) UCX®-derived CMN or CMH protect HL-1 cardiomyocytes from apoptosis (induced by hypoxia during 48 hours), as shown by the detection of apoptotic cells by TUNEL assay. (F) The percentage of apoptotic cells increases when cells are subjected to hypoxia for 48 hours, both in serum-containing (31.93% ± 1.59%) and serum-free BM medium (47.73% ± 2.02%). Importantly, when media are supplemented with UCX® conditioned media, the percentage of apoptotic cells is significantly decreased (CMN – 24.77% ± 1.70%; CMH – 23.67% ± 1.95%). ***P < 0.0001, n = 4.

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