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Figure 5 | Stem Cell Research & Therapy

Figure 5

From: Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapoptotic, and endogenous cell-activation mechanisms

Figure 5

Paracrine effect of UCX® on CPCs proliferation and cardiac commitment. Treatment of Sca-1+ CPCs with UCX®-derived conditioned media for 72 hours results in enhanced metabolic activity (A) and cellular proliferation (B), when compared with the treatment with basal medium (n = 4; *P < 0.05; **P < 0.01; ***P < 0.0001). (C through E) Treatment with UCX®-derived CMH and, to a lesser extent, CMN triggers CPCs cardiac commitment, as shown by higher expression of early (Gata4, Nkx2.5) and late (Myh6) cardiac-affiliated markers in comparison with basal-medium treated CPCs (n = 3; values were normalized to those of standard culture conditions: BM + 10% FBS, represented by the dotted lines in each graph. *P < 0.05; **P < 0.01, either between groups indicated in brackets, or between BM + 10% FBS and the group represented by the asterisk placed above its corresponding column).

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