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Figure 1 | Stem Cell Research & Therapy

Figure 1

From: Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells

Figure 1

Characterization of decellularized myocardial infarcts as a function of remodeling time. (A) The decellularized scar appears physically distinct from the noninfarcted region of the myocardium. (B) Representative confocal images acquired 25 μm from tissue surface. Composite images demonstrate an increase in collagen deposition after infarct (Forward SHG in red, backward SHG in green, two-photon excited fluorescence (TPEF) emission between 500 and 550 nm in blue). (C) Representative stress–strain curves derived from mechanically testing decellularized myocardial strips derived from both healthy left ventricular tissue and 4-week scar tissue. (D) The tangent modulus of the left ventricle increases with remodeling time after myocardial infarction (n = 4 to 6 for each condition).

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