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Figure 10 | Stem Cell Research & Therapy

Figure 10

From: Glutathione S-transferase Mu 2-transduced mesenchymal stem cells ameliorated anti-glomerular basement membrane antibody-induced glomerulonephritis by inhibiting oxidation and inflammation

Figure 10

Human glutathione S-transferase Mu 2 mesenchymal stem cells (hGSTM2-MSCs) suppressed renal oxidative reaction. Immunohistochemical assay on cells positive for inducible nitric oxide synthase (iNOS), catalase (CAT) or glutathione peroxidase 1 (GPX1) in renal slides. (A) hGSTM2-MSC treatment significantly reduced the number of iNOS-positive cells compared with pCDH-MSC (vector) treatment. (B-C) The numbers of CAT-positive and GPX1-positive cells were significantly higher in hGSTM2-MSC-treated mice compared with control mice. (D) Nitric oxide (NO) level in the kidneys of mice treated with pCDH-MSCs and hGSTM2-MSCs. NO was reduced in the kidneys of hGSTM2-MSC-treated mice compared with pCDH-MSC-treated mice (P<0.05). (E) CAT and (F) superoxide dismutase (SOD) activities were significantly increased in the kidneys of hGSTM2-MSC-treated mice compared with pCDH-MSC-treated mice (P<0.05).

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