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Figure 4 | Stem Cell Research & Therapy

Figure 4

From: Myocardial transfection of hypoxia-inducible factor-1α and co-transplantation of mesenchymal stem cells enhance cardiac repair in rats with experimental myocardial infarction

Figure 4

Migration and differentiation of engrafted MSCs after cell injection. A) Migration of mesenchymal stem cells (MSCs) at four weeks after cell injection from the border zone to infarcted region. Engrafted MSCs stained with DiR, which were injected originally in the peri-infarcted region, were detected in the infarcted region. The figures demonstrated MSCs engrafted in the infarcted region. B) Engrafted MSCs contribute to the angiogenesis three weeks after cell injection, in the peri-infarcted region of hearts of hypoxia-inducible factor-1α (HIF-1α) + MSCs group. Engrafted MSCs were stained with DiR (red) before cell injection. The arrow indicates CD31+ engrafted MSCs stained with DiR. Samples were stained with anti-CD31 antibody (green) and 4, 6-diamino-2-phenylindole (DAPI) (blue).

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Stem Cell Research & Therapy

ISSN: 1757-6512