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Table 1 Differential expression analysis in primary human neonatal ADSC

From: Human adipose-derived stem cell transplantation as a potential therapy for collagen VI-related congenital muscular dystrophy

Gene symbol

RefSeq number

Description

Signal

Fold difference gene/GAPDHa

Extracellular matrix proteins

Collagens and ECM structural constituents

COL1A1

NM_000088

Homo sapiens collagen, type I, alpha 1

183526

2.06

COL1A2

NM_000089

Homo sapiens collagen, type I, alpha 2

142138

1.59

COL3A1

NM_000090

Homo sapiens collagen, type III, alpha 1

3108

0.03

COL4A1

NM_001845

Homo sapiens collagen, type IV, alpha 1

5622

0.06

COL4A2

NM_001846

Homo sapiens collagen, type IV, alpha 2

44164

0.49

COL5A1

NM_000093

Homo sapiens collagen, type V, alpha 1

32129

0.36

COL5A2

NM_000393

Homo sapiens collagen, type V, alpha 2

19919

0.22

COL6A1

NM_001848

Homo sapiens collagen, type VI, alpha 1

117011

1.31

COL6A2

NM_058174

Homo sapiens collagen, type VI, alpha 2

11593

0.13

COL6A3

NM_004369

Homo sapiens collagen, type VI, alpha 3

1112

0.01

COL7A1

NM_000094

Homo sapiens collagen, type VII, alpha 1

1136

0.01

COL12A1

NM_004370

Homo sapiens collagen, type XII, alpha 1

17353

0.19

COL16A1

NM_001856

Homo sapiens collagen, type XVI, alpha 1

17366

0.19

DCN

NM_001920

Homo sapiens decorin

22826

0.25

FN1

NM_054034

Homo sapiens fibronectin 1

6213

0.07

LUM

NM_002345

Homo sapiens lumican

7747

0.09

Basement membrane constituents

LAMA2

NM_000426

Homo sapiens laminin, alpha 2

804

0.01

LAMB1

NM_002291

Homo sapiens laminin, beta 1

10371

0.11

LAMB2

NM_002292

Homo sapiens laminin, beta 2 (laminin S)

16172

0.18

LAMC1

NM_002293

Homo sapiens laminin, gamma 1 (formerly LAMB2)

10072

0.11

Cell adhesion molecules

Cell-matrix adhesion

ITGA5

NM_002205

Homo sapiens integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

3324

0.04

ITGA6

NM_000210

Homo sapiens integrin, alpha 6

1168

0.01

ITGA7

NM_002206

Homo sapiens integrin, alpha 7

7553

0.08

ITGB1

NM_133376

Homo sapiens integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

6616

0.07

ITGB5

NM_002213

Homo sapiens integrin, beta 5

4324

0.05

ECM proteases and protease inhibitors

MMP1

NM_002421

Homo sapiens matrix metallopeptidase 1 (interstitial collagenase)

4368

0.05

TIMP1

NM_003254

Homo sapiens TIMP metallopeptidase inhibitor 1

42809

0.48

TIMP2

NM_003255

Homo sapiens TIMP metallopeptidase inhibitor 2

83481

0.93

TIMP3

NM_000362

Homo sapiens TIMP metallopeptidase inhibitor 3

36463

0.41

Non-muscle and muscle markers

DES

NM_001927

Homo sapiens desmin

8119

0.09

MYO1C

NM_033375

Homo sapiens myosin IC

33956

0.38

MYLK

NM_053025

Homo sapiens myosin light chain kinase

12346

0.14

MYLK

NM_053025

Homo sapiens myosin light chain kinase

18846

0.21

MYH9

NM_002473

Homo sapiens myosin, heavy chain 9, non-muscle

15884

0.18

MYL6

NM_079423

Homo sapiens myosin, light chain 6, alkali, smooth muscle and non-muscle

51777

0.58

  1. aThe fold difference represents the ratio of intensity of each gene hybridized with the RNA isolated from hADSC normalized to the intensity of GAPDH gene. Each array was processed in an identical manner and the number represents an average of triplicate experiments from three independent cell isolates. Each gene is demarcated by the Genbank accession number, the description of the gene and the common name. Genes are grouped by their distinct functional categories. ADSC, adipose-derived stem cells; ECM, extracellular matrix.
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Stem Cell Research & Therapy

ISSN: 1757-6512