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Figure 1 | Stem Cell Research & Therapy

Figure 1

From: Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling

Figure 1

Upregulation of wound healing genes by human Wharton's jelly-derived mesenchymal stem cell conditioned medium in human normal skin fibroblasts. (A-L) mRNA transcript expression relative to 18S after 7 days of culture of human normal skin fibroblasts with Wharton's jelly-derived mesenchymal stem cell conditioned medium (WJ-MSC-CM; treatment group) or nonconditioned medium (control group) from five different patients (but four patients for FGF-2 and three patients for collagen I, collagen III and decorin). Overall, WJ-MSC-CM enhanced a wound healing promoting phenotype in human normal skin fibroblasts in our culture conditions. *P ≤ 0.05. COL, collagen; CTGF, connective tissue growth factor; FGF-2, fibroblast growth factor-2; HIF-1α, hypoxia-inducible factor-1α; PAI-1, plasminogen activator inhibitor-1; TGF-β, transforming growth factor beta; VEGF, vascular endothelial growth factor.

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