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Table 1 SB623-to-parental MSC ratios of neuropoietic coefficients

From: Comparison of the neuropoietic activity of gene-modified versus parental mesenchymal stromal cells and the identification of soluble and extracellular matrix-related neuropoietic mediators

 

Nes

CNP

GFAP

Donor A

3.6

3.2

1.3

Donor B

3.9

3.5

7.3

Donor C

1.1

2.6

1.1

Donor D

1.4

2.9

1.9

Donor E

5.5

2.1

1.8

Donor F

2.3

1.8

2

Average

3

2.7

2.6

SD

1.68

0.65

2.35

  1. Neuropoietic coefficients characterize the ability of MSCs or SB623 to induce a corresponding rat neural marker in defined conditions of the microplate neuropoiesis coculture assay. Pairs of SB623 and parental MSCs from six donors were compared in the assay; and neuropoietic coefficients for nestin, GFAP, and CNP were calculated, as explained in Figure 1, based on qRT-PCR data. The table represents ratios of SB623 to MSC coefficients for six donors; average ratios and standard deviations (SD) are in bold.
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Stem Cell Research & Therapy

ISSN: 1757-6512