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Table 1 Efficacy of various stem cell populations/carriers in small preclinical tendon defect models

From: Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models

Experimental details Accelerated tendon healing Enhanced tendon strength Improved tendon histology Reference
Allogeneic BMSCs with fibrin hydrogel Rabbit Achilles or rat patellar tendon X [126128]
Autologous ADSCs with PRP hydrogel Rabbit Achilles tendon [61]
Autologous BMSCs with collagen I hydrogel Rabbit Achilles tendon X [55]
Autologous BMSCs with PLGA sheet Rabbit rotator cuff tendon [115]
Allogeneic ACL-derived CD34+ cell sheet with tendon graft Rat ACL [81]
Autologous ADSCs with heparin, fibrin and PDGF BB hydrogel on electro-spun PLGA Dog flexor digitorum profundus tendon    [119]
Embryonic stem cell sheets Rat patellar tendon [129]
Induced pluripotent stem cells and fibrin gel Rat patellar tendon [130]
TSC sheet Rat patellar tendon [131]
Engineered BMSCs on collagen scaffold Rat Achilles tendon [132134]
  1. A tick indicates a positive outcome and a cross indicates a negative/suboptimal improvement compared to control. Entries are blank when the study did not assess the parameter mentioned. ACL, anterior cruciate ligament; ADSC, adipose-derived stem cell; BMSC, bone marrow-derived mesenchymal stem cell; PDGF BB, platelet derived growth factor BB; PLGA, polylactide-co-glycolide; PRP, platelet rich plasma; TSC, tendon stem cell.