Table 1 Efficacy of various stem cell populations/carriers in small preclinical tendon defect models
From: Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models
Experimental details | Accelerated tendon healing | Enhanced tendon strength | Improved tendon histology | Reference |
|---|---|---|---|---|
Allogeneic BMSCs with fibrin hydrogel Rabbit Achilles or rat patellar tendon | X | ✓ | ✓ | |
Autologous ADSCs with PRP hydrogel Rabbit Achilles tendon | ✓ | ✓ | ✓ | [61] |
Autologous BMSCs with collagen I hydrogel Rabbit Achilles tendon | X | ✓ | ✓ | [55] |
Autologous BMSCs with PLGA sheet Rabbit rotator cuff tendon | ✓ | ✓ | ✓ | [115] |
Allogeneic ACL-derived CD34+ cell sheet with tendon graft Rat ACL | ✓ | ✓ | ✓ | [81] |
Autologous ADSCs with heparin, fibrin and PDGF BB hydrogel on electro-spun PLGA Dog flexor digitorum profundus tendon | ✓ | [119] | ||
Embryonic stem cell sheets Rat patellar tendon | ✓ | ✓ | ✓ | [129] |
Induced pluripotent stem cells and fibrin gel Rat patellar tendon | ✓ | ✓ | ✓ | [130] |
TSC sheet Rat patellar tendon | ✓ | ✓ | ✓ | [131] |
Engineered BMSCs on collagen scaffold Rat Achilles tendon | ✓ | ✓ | ✓ |