MRI of the aorta. Cross sections of the origin of the ascending aortas seen by spin-echo magnetic resonance imaging (MRI) in a wild type (A) and an mLMNA + (B) mouse. Images include the ascending aorta in cross-section, the right atrium and the pulmonary artery, annotated on image (A). The measured area for aortic wall thickness and lumen cross sectional area are shown in the bottom row with two regions of interest (ROIs) indicating the inner and outer borders of the aortic wall in the wild type (WT) (C) and mLMNA+ mouse (D). The lumenal cross section is the area of the inner region of interest (ROI) multiplied by the slice thickness; the wall area is the area between the two ROI outlines multiplied by the slice thickness. Lumen diameter (mm) (E) and aorta area (mm2) (F) of wild type and mLMNA+ mice (n = 3).