Figure 1From: Inositol pyrophosphates mediate the effects of aging on bone marrow mesenchymal stem cells by inhibiting Akt signalingCharacterization of mesenchymal stem cells from both aged and young mice. (A) MSCs from both young and aged donor mice display fibroblast-like morphology. The pluripotency of MSCs from both young and aged mice was confirmed by adipogenic and osteogenic differentiation assays which were detected by Oil red O staining and alizarin red S staining, respectively. (B) Flow cytometry results show that MSCs from both young and aged donor mice were uniformly negative for CD34 and CD45, and positive for CD44 and CD90 (n = 5). MSCs, mesenchymal stem cells.Back to article page