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Figure 6 | Stem Cell Research & Therapy

Figure 6

From: Inositol pyrophosphates mediate the effects of aging on bone marrow mesenchymal stem cells by inhibiting Akt signaling

Figure 6

TNP enhanced paracrine efficiency of aged MSCs. (A) Representative RT-PCR results of the mRNA levels of VEGF, bFGF, IGF-1 and HGF in young MSCs, aged MSCs and even aged MSCs with TNP. The protein expressions of VEGF (B), bFGF (C), IGF-1 (D) and HGF (E) were measured by ELISA assays. Data are expressed as mean ± SEM. n = 5, *P <0.05. bFGF, basic fibroblast growth factor; HGF, hepatocyte growth factor; IGF-1, insulin-like growth factor-1; MSCs, mesenchymal stem cells; SEM, standard error of the mean; TNP, N6-(p-nitrobenzyl) purine; VEGF, vascular endothelial growth factor.

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