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Table 1 Reports of expression/functional profiles recently found to identify putative human nasopharyngeal cancer stem-like cells

From: Cancer stem-like cell: a novel target for nasopharyngeal carcinoma therapy

Expression/functional profile Cells/tissues studied Characteristics of cancer stem cell identity
Label-retaining cells 5-8 F, 6-10B and TMNE Increased clonogenicity, tumor formation in mice at low titers [16, 17]
Label-retaining cells (PKH26+) CNE1, CNE2, SUNE1, and HONE1 Longevity, sphere formation, side population cells, and resistance to radiotherapy [18]
Side population cells CNE-2 Strong tumorigenesis ability, more resistant to chemotherapy and radiotherapy, cytokine 19 positive [24]
Side population cells (ABCG2+) 5-8 F ABCG2 alone is not sufficient, PSCA, ABCG2 and ALP were expressed in ABCG2+ cells, and K19, integrin α6, integrin β4, CD44 and K14 were expressed in ABCG2 cells [25]
ALDH1high cells or ALDH1A1 5-8 F and CNE2 High ALDH1 activity, higher clone formation efficiency, differentiation capability and higher migration, enhanced capacities of growth, proliferation, and tumorigenesis,5 to 103 ALDH1high NPC cells required to induce tumors, vimentin+, and E-cadherin,OCT4, SOX2 and Nanog+[27, 28]
C666-1 Significantly greater ability to proliferate, be clonogenic, resist chemotherapy drugs and radiation, and express pluripotent markers, tumor formation at a higher rate [2931]
CD44+ 5-8 F, C666-1 Higher survival rate, resist chemotherapy drugs [35, 36]
CD133+ CNE2 and primarily cultured NPC cells Nanog+ and Sox2+, a strong potential for self-renewal, sphere formation, proliferation and differentiation and a greater potential for in vivo tumor formation in nude mice [39]
Sphere-forming cells C666-1 CD44+ and SOX2+, higher spheroid formation efficiency, resistant to chemotherapeutic agents, CCR7+ associated recurrent disease and distant metastasis [48]
  1. ABCG2 ATP-binding cassette sub-family G member 2; ALDH1 aldehyde dehydrogenase 1; NPC nasopharyngeal carcinoma.