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Figure 2 | Stem Cell Research & Therapy

Figure 2

From: Intraarterial transplantation of human umbilical cord blood mononuclear cells is more efficacious and safer compared with umbilical cord mesenchymal stromal cells in a rodent stroke model

Figure 2

Reduced neurologic deficits in all three cell-treated stroke animals with enhanced recovery in the cbMNC group. Neurologic deficits were assessed on rotarod (A), open field (B), and foot-fault (C) tests before stroke (d 0) and at d 1, 4, 7, and 14 after stroke. Rotarod motor coordination of all cell-treated animals improved significantly compared with the PBS group. P < 0.01 (d4), P < 0.001 (d 7, 14) for cbMNC group; P < 0.05 (d 4) and P < 0.01 (d 7, 14) for cbMSC and cmMSC groups. Significant improvement in open-field spontaneous activity was seen at d 14 in cbMNC- and cbMSC-treated animals, but not in the cmMSC group compared with the PBS group (P < 0.01 and P < 0.05, respectively). Significant reduction in percentage foot faults was seen in the cbMNC group relative to the PBS group (P < 0.01, d 7 and P < 0.001, d 14) and the cmMSC group (P < 0.05, d 14). cbMSC- but not cmMSC-treated animals showed significant reduction in limb misplacement at d 14 (P < 0.01). Relative to the PBS group, only the cbMNC group showed significantly less contralateral forelimb errors (D) (P < 0.01 at d 4; P < 0.05 at d 7, 14); however, both cbMSC and cbMNC groups showed recovery in contralateral hindlimb errors at d 14 (E) (P < 0.01 and P < 0.05, respectively). At d 14, relative to the sham group, no significant difference was seen in contralateral forelimb errors in the cbMNC group and in hindlimb errors in both cbMNC and cbMSC groups (D, E). (*) is P < 0.05; (**) is P < 0.01, and (***) is P < 0.001. Values are expressed as mean ± SEM.

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