Figure 7
Quantification of mRNA expression of rat-specific BDNF, GPx-4, EGF, reelin, IL-2, IL-6, IL-1beta, and TNF-alpha in the ipsilateral hemisphere. At 2 weeks after stroke, rat BDNF mRNA expression in sham rats was significantly more compared with PBS (P < 0.0001), cbMNC (P < 0.01), and cb/cmMSC (P < 0.001) groups. Rat BDNF mRNA expression was relatively more in the cbMNC group compared with the cb/cmMSC and PBS groups. No significant difference was seen in expression of rat EGF, reelin, GPx-4, and TNF-alpha across the cell-treated, sham, and PBS groups, although there was an enhanced expression of GPx-4 and reelin mRNA in cbMNC and sham animals. Significantly decreased IL-2 mRNA expression was seen in the cb/cmMSC groups (P < 0.001). Compared with the PBS group, expression of IL-6 mRNA was significantly less in cbMSC- and sham-group animals (P < 0.001). Significantly decreased expression of rat IL-1beta mRNA was seen only in the cbMSC group (P < 0.001). Values are expressed as mean ± SEM, (*) is P < 0.05; (**) is P < 0.01; (***) is P < 0.001; and (****) is P < 0.0001.