Table 1 Percentage expression of phenotypic cell markers in cbMSCs, cmMSCs, and cbMNCs
Marker | cbMSC | cmMSC | cbMNC | Function of marker |
|---|---|---|---|---|
CD7 | 0.407 | 5.4 | 62.51 | Marker for thymocytes and mature T cells |
CD4 | 5.88 | 68.0 | 26.77 | Marker for T-helper cells, regulatory T cells, monocytes |
CD25 | 91.2 | 71.3 | 71.8 | Part of IL-2 receptor present on activated T cells/B cells |
CD3 | 36.3 | 4.33 | 31.3 | T-cell coreceptor and marker for mature T cells |
CD8 | 0.123 | 0.277 | 21.1 | Coreceptor for T-cell receptor and binds specifically to major histocompatibility complex (MHC) I |
CD44 | 100 | 99.7 | 81.7 | Marker for effector memory T cells, lymphocyte activation, receptor for hyaluronic acid |
HLA-ABC | 96.9 | 98.8 | 92.4 | MHC Class I |
CD90 | 73.5 | 99.8 | 36.5 | Marker for mesenchymal stem cells, hematopoietic stem cells (HSCs), and fibroblasts |
CD56 | 1.28 | 80.8 | 11.3 | Neuronal cell-adhesion molecule, plays role in synaptic plasticity and neurite outgrowth |
CD210 | 91.8 | 96.5 | 0.544 | IL-10 receptor on T cells/B cells, natural killer (NK) cells, and monocytes |
CD45 | 0.99 | 0.82 | 87.7 | Leukocyte common antigen |
CD14 | 0.404 | 20.3 | 12.4 | Monocyte differentiation antigen |
CD34 | 0.124 | 1.57 | 0.80 | Marker for primitive hematopoietic and endothelial stem cells |
CD133 | 0.11 | 0.899 | 0.897 | Prominin-1, specific for hematopoietic stem cells, endothelial progenitors, neuronal and glial stem cells |
CD117 | 99.5 | 92.9 | 2.2 | Stem cell growth-factor receptor, expressed on HSCs, multipotent progenitors, common myeloid progenitors |
CD73 | 100 | 99.5 | 5.75 | Lymphocyte differentiation marker |
CD123 | 91.8 | 48.8 | 1.81 | IL-3 receptor on pluripotent progenitors |
CD16 | 31.5 | 72 | 81.9 | Marker for NK cells, monocytes, and macrophages |
CD166 | 100 | 99.8 | 3.38 | Activated leukocyte cell-adhesion molecule |
Lin1 | 0.46 | 31.6 | 87.2 | Lineage cocktail 1 (CD3, 14, 16, 19, 20, 56) |
CD59 | 99.8 | 99.3 | 7.14 | Complement regulatory protein, regulates complement-mediated cell lysis by formation of membrane-attack complex |
CD106 | 16.21 | 23.0 | 3.54 | Vascular cell-adhesion molecule (VCAM)-1 |
CD184 | 100 | 75.6 | 64.4 | Chemokine (C-X-C motif) receptor-4 specific for stromal-derived factor-1 |
HLA-DR | 0.434 | 0.312 | 31.6 | MHC Class II |
CD19 | 6.89 | 0.399 | 9.27 | Marker for follicular dendritic cells and B cells |
CD33 | 1.26 | 0.313 | 27.3 | Marker for myeloid-lineage cells |