Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells

Table 1 Characteristics of various types of pluripotent stem cells

Stem cell type	Donor cell type	Reprogramming factors/systems	Teratoma formation	Chimera formation	Pluripotency marker expression			Reference
Stem cell type	Donor cell type	Reprogramming factors/systems	Teratoma formation	Chimera formation	SSEA1	SSEA3/4	OCT4,SOX2, NANOG	Reference
MESCs	Embryo	-	+	+	+	-	+	[9]
HESCs	Embryo	-	+	ND	-	+	+	[7]
MEpiSCs	Epiblast	-	+	-	+	-	+	[90]
MiPSCs	Neural stem cell	OCT4, viral	+	+	+	_	+	[91]
HiPSCs	Amnion	SOX2, plasmid electroporation	+	ND	-	+	+	[82]
MiPSCs-C	Melanoma	OCT4, c-MYC, KLF4, viral	+	+	ND	ND	ND	[43]
HiPSCs-C	Colorectal cancer	OCT4, c-MYC, SOX2, KLF4, viral	+	ND	-	+	+	[92]
HiPSCs-C	Melanoma	miRNA, viral	+	ND	-	+	+	[93]

Human and murine pluripotent stem cells are characterized as described in the cited references. HESCs, human embryonic stem cells; HiPSCs, human induced pluripotent stem cells; HiPSCs-C, human induced pluripotent stem cells from cancer; MEpiSCs, murine epiblast stem cells; MESCs, murine embryonic stem cells; MiPSCs, murine induced pluripotent stem cells; MiPSCs-C, murine induced pluripotent stem cells from cancer; ND, not determined.

ISSN: 1757-6512