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Table 1 Characteristics of various types of pluripotent stem cells

From: Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells

Stem cell type Donor cell type Reprogramming factors/systems Teratoma formation Chimera formation Pluripotency marker expression Reference
SSEA1 SSEA3/4 OCT4,SOX2, NANOG
MESCs Embryo - + + + - + [9]
HESCs Embryo - + ND - + + [7]
MEpiSCs Epiblast - + - + - + [90]
MiPSCs Neural stem cell OCT4, viral + + + _ + [91]
HiPSCs Amnion SOX2, plasmid electroporation + ND - + + [82]
MiPSCs-C Melanoma OCT4, c-MYC, KLF4, viral + + ND ND ND [43]
HiPSCs-C Colorectal cancer OCT4, c-MYC, SOX2, KLF4, viral + ND - + + [92]
HiPSCs-C Melanoma miRNA, viral + ND - + + [93]
  1. Human and murine pluripotent stem cells are characterized as described in the cited references. HESCs, human embryonic stem cells; HiPSCs, human induced pluripotent stem cells; HiPSCs-C, human induced pluripotent stem cells from cancer; MEpiSCs, murine epiblast stem cells; MESCs, murine embryonic stem cells; MiPSCs, murine induced pluripotent stem cells; MiPSCs-C, murine induced pluripotent stem cells from cancer; ND, not determined.