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Table 2 A list of statistically significant ( P< 0.001) genes with indicated fold changes (Log 2 (fold change))

From: Gene markers of cellular aging in human multipotent stromal cells in culture

Number

Gene accession number

Gene name

Gene symbol

Location

Mean fold change (MFC)

Technical variability

Biologic variability

(P7/P3)

(P5/P3)

(P7/P5)

P7/P3 (Log2(MFC))

P5/P3 (Log2(MFC))

P7/P5 (Log2(MFC))

1

NM_003816

ADAM metallopeptidase domain 9

ADAM9

Plasma membrane

1.25 (0.321)

NS

NS

0.112

0.226

-

-

2

XM_005248381

ADAM 7metallopeptidase with thrombospondin type 1 motif, 12

ADAMTS12

Unknown

1.59 (0.672)

NS

NS

0.143

0.477

-

-

3

NM_018238

Acylglycerol kinase

AGK

Cytoplasm

−1.10 (−0.133)

NS

−1.13 (−0.170)

0.128

0.110

-

0.163

4

NM_001199183

ATPase, Ca2 transporting, type 2C, member 1

ATP2C1

Cytoplasm

1.47 (0.555)

NS

NS

0.101

0.325

-

-

5

NM_006886

ATP synthase, H + transporting, mitochondrial F1 complex, epsilon subunit

ATP5E

Cytoplasm

1.10 (0.142)

1.10 ([0.133)

NS

0.092

0.069

0.084

-

6

NM_000489

Alpha thalassemia/mental retardation syndrome X-linked

ATRX

Nucleus

1.18 (0.242)

NS

NS

0.108

0.191

-

-

7

NM_024812

Brain and acute leukemia, cytoplasmic

BAALC

Cytoplasm

−2.33 (−1.223)

NS

NS

0.105

0.509

-

-

8

NM_015379

Brain protein I3

BRI3

Unknown

1.26 (0.333)

NS

NS

0.112

0.237

-

-

9

NM_004334

Bone marrow stromal cell antigen 1

BST1

Plasma membrane

2.46 (1.297)

NS

NS

0.134

0.595

-

-

10

NM_001206748

Caveolin 2

CAV2

Plasma membrane

1.35 (0.438)

NS

NS

0.207

0.309

-

-

11

NM_174908

Coiled-coil domain containing 50

CCDC50

Cytoplasm

1.25 (0.322)

NS

NS

0.113

0.194

-

-

12

NM_003903

Cell division cycle 16 homolog (Saccharomyces cerevisiae)

CDC16

Nucleus

1.16 (0.218)

NS

NS

0.093

0.059

-

-

13

NM_006319

CDP-diacylglycerol-inositol 3-phosphatidyltransferase

CDIPT

Cytoplasm

1.27 (0.345)

NS

NS

0.173

0.270

-

-

14

NM_001799

Cyclin-dependent kinase 7

CDK7

Nucleus

1.21 (0.278)

NS

NS

0.107

0.143

-

-

15

NM_001195132

Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

CDKN2A

Nucleus

1.37 (0.452)

NS

NS

0.104

0.402

-

-

16

NM_001854

Collagen, type XI, alpha 1

COL11A1

Extracellular space

−2.19 (−1.132)

NS

NS

0.243

0.947

-

-

17

NM_004370

Collagen, type XII, alpha 1

COL12A1

Extracellular space

−3.00 (−1.583)

NS

NS

0.185

0.895

-

-

18

NM_032609

Cytochrome c oxidase subunit IV isoform 2 (lung)

COX4I2

Cytoplasm

−1.33 (−0.407)

NS

NS

0.140

0.183

-

-

19

NM_000100

Cystatin B (stefin B)

CSTB

Cytoplasm

1.25 (0.323)

NS

NS

0.078

0.262

-

-

20

NG_021375

Discs, large homolog 2 (Drosophila)

DLG2

Unknown

1.43 (0.521)

NS

NS

0.106

0.263

-

-

21

NM_025219

DNAJ (Hsp40) homolog, subfamily C, member 5

DNAJC5

Plasma membrane

1.27 (0.342)

NS

NS

0.134

0.289

-

-

22

NM_005740

Dynein, axonemal, light chain 4

DNAL4

Cytoplasm

1.54 (0.626)

NS

NS

0.138

0.335

-

-

23

NM_001009933

Deoxyribonuclease I-like 1

DNASE1L1

Cytoplasm

1.47 (0.559)

NS

NS

0.102

0.336

-

-

24

NM_033407

Dedicator of cytokinesis 7

DOCK7

Plasma membrane

1.29 (0.370)

NS

NS

0.116

0.249

-

-

25

NM_020390

Eukaryotic translation initiation factor 5A2

EIF5A2

Cytoplasm

1.17 (0.227)

NS

NS

0.142

0.115

-

-

26

NM_014568

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)

GALNT5

Cytoplasm

2.01 (1.005)

1.63 (0.705)

NS

0.074

0.620

0.216

-

27

NM_001523

Hyaluronan synthase 1

HAS1

Plasma membrane

−1.84 (−0.882)

−1.42 (−0.507)

NS

0.112

0.136

0.132

-

28

XM_005249437

Histone cluster 1, H2ac

HIST1H2AC

Unknown

1.99 (0.992)

NS

NS

0.159

0.904

-

-

29

NM_003535

Histone cluster 1, H3j

HIST1H3J

Nucleus

−1.22 (−0.286)

NS

NS

0.136

0.200

-

-

30

NM_001130688

High-mobility group box 2

HMGB2

Nucleus

−1.18 (−0.239)

NS

NS

0.082

0.135

-

-

31

XM_005266269

Heterogeneous nuclear ribonucleoprotein A1-like 2

HNRNPA1L2

Unknown

−1.47 (−0.557)

NS

NS

0.084

0.489

-

-

32

NM_004791

Integrin, beta-like 1 (with EGF-like repeat domains)

ITGBL1 a(2)

Unknown

1.56 (0.639)

NS

NS

0.120

0.504

-

-

33

NM_015167

Jumonji domain containing 6

JMJD6

Plasma membrane

−1.16 (−0.220)

NS

NS

0.100

0.108

-

-

34

NG_028043

Kinesin family member 16B

KIF16B

Cytoplasm

2.04 (1.027)

1.62 (0.697)

NS

0.094

0.547

0.175

-

35

NM_001300

Kruppel-like factor 6

KLF6

Nucleus

−1.43 (−0.518)

NS

NS

0.148

0.086

-

36

NM_000223

Keratin 12

KRT12

Cytoplasm

1.51 (0.598)

NS

NS

0.234

0.377

-

37

NM_199187

Keratin 18

KRT18 a(16)

Cytoplasm

3.62 (1.813)

2.34 (1.205)

NS

0.157

0.891

0.497

-

38

NM_001080978

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2

LILRB2

Plasma membrane

1.11 (0.156)

NS

NS

0.151

0.147

-

-

39

NM_144703

LSM14B, SCD6 homolog B (Saccharomyces cerevisiae)

LSM14B

Unknown

−1.12 (−0.165)

NS

NS

0.116

0.118

-

-

40

NM_020152

MAP3K7 C-terminal like

MAP3K7CL

Unknown

2.36 (1.238)

NS

NS

0.13

0.962

-

-

41

NG_013325

Mitogen-activated protein kinase 10

MAPK10

Cytoplasm

−1.15 (−0.201)

−1.15 (−0.199)

NS

0.146

0.172

0.196

-

42

NM_138799

Membrane bound O-acyltransferase domain containing 2

MBOAT2

Cytoplasm

−1.26 (−0.338)

NS

NS

0.105

0.279

-

-

43

NR_002766

Maternally expressed 3 (nonprotein coding)

MEG3

Unknown

1.41 (0.505)

NS

NS

0.218

0.359

-

-

44

NM_001130156

Myeloid leukemia factor 1

MLF1

Nucleus

−1.22 (−0.289)

−1.19 (−0.256)

NS

0.126

0.126

0.068

-

45

NM_170738

Mitochondrial ribosomal protein L11

MRPL11

Cytoplasm

−1.17 (−0.230)

NS

NS

0.141

0.135

-

-

46

NM_002489

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9 kDa

NDUFA4

Cytoplasm

1.25 (0.327)

NS

NS

0.107

0.257

-

-

47

NM_001018138

Nonmetastatic cells 2, protein (NM23B) expressed in

NME2

Nucleus

NS

1.13 (0.171)

NS

0.099

-

0.156

-

48

NM_021229

Netrin 4

NTN4 a(2)

Extracellular space

2.68 (1.401)

NS

NS

0.173

0.584

-

-

49

NM_000436

3-Oxoacid CoA transferase 1

OXCT1

Cytoplasm

−1.29 (−0.365)

NS

NS

0.116

0.312

-

-

50

NM_182904

Prolyl 4-hydroxylase, alpha polypeptide III

P4HA3

Unknown

−1.19 (−0.250)

NS

NS

0.080

0.179

-

-

51

NM_006451

Poly(A) binding protein interacting protein 1

PAIP1

Cytoplasm

−1.22 (−0.284)

NS

NS

0.104

0.118

-

-

52

NM_006197

Pericentriolar material 1

PCM1

Cytoplasm

−1.20 (−0.265)

NS

NS

0.138

0.172

-

-

53

NM_006211

Proenkephalin

PENK

Extracellular space

−4.15 (−2.052)

NS

NS

0.161

0.915

-

-

54

NM_002653

Paired-like homeodomain 1

PITX1

Nucleus

−1.17 (−0.232)

NS

−1.17 (−0.236)

0.151

0.209

-

0.214

55

NM_001172335

Plastin 3

PLS3

Cytoplasm

1.43 (0.515)

NS

NS

0.136

0.298

-

-

56

NM_006406

Peroxiredoxin 4

PRDX4

Cytoplasm

1.23 (0.301)

NS

NS

0.102

0.206

-

-

57

NM_182663

Ras association (RalGDS/AF-6) domain family member 5

RASSF5

Plasma membrane

1.93 (0.947)

NS

NS

0.118

0.553

-

-

58

NM_006867

RNA-binding protein with multiple splicing

RBPMS a(2)

Unknown

1.23 (0.298)

NS

NS

0.111

0.111

-

-

59

NM_006802

Splicing factor 3a, subunit 3, 60 kDa

SF3A3

Nucleus

−1.26 (−0.333)

NS

NS

0.130

0.284

-

-

60

NM_003028

Src homology 2 domain containing adaptor protein B

SHB

Cytoplasm

1.33 (0.407)

NS

NS

0.118

0.203

-

-

61

NM_001142392

Solute carrier family 10 (sodium/bile acid cotransporter family), member 3

SLC10A3

Plasma membrane

1.20 (0.261)

NS

NS

0.184

0.156

-

-

62

NM_005072

Solute carrier family 12 (potassium/chloride transporters), member 4

SLC12A4

Plasma membrane

1.34 (0.424)

NS

NS

0.118

0.278

-

-

63

NM_005073

Solute carrier family 15 (oligopeptide transporter), member 1

SLC15A1

Plasma membrane

1.17 (0.228)

NS

NS

0.201

0.109

-

-

64

NM_001166695

Solute carrier family 1 (glial high-affinity glutamate transporter), member 3

SLC1A3

Plasma membrane

−1.72 (−0.786)

NS

NS

0.183

0.352

-

-

65

NM_032315

Solute carrier family 25, member 33

SLC25A33

Cytoplasm

−1.12 (−0.164)

NS

NS

0.144

0.139

-

-

66

NM_152313

Solute carrier family 36 (proton/amino acid symporter), member 4

SLC36A4

Unknown

−1.18 (−0.239)

NS

NS

0.124

0.156

-

-

67

NM_001013843

SAFB-like, transcription modulator

SLTM

Nucleus

−1.15 (−0.196)

NS

NS

0.122

0.146

-

-

68

NM_003795

Sorting nexin 3

SNX3

Cytoplasm

1.22 (0.293)

NS

NS

0.126

0.279

-

-

69

NM_152343

Spermatogenesis associated 32

SPATA32

Unknown

−1.17 (−0.229)

NS

NS

0.097

0.153

-

-

70

NM_004598

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

SPOCK1

Extracellular space

2.07 (1.052)

NS

NS

0.148

0.729

-

-

71

NM_001159673

Synaptotagmin binding, cytoplasmic RNA interacting protein

SYNCRIP

Nucleus

−1.24 (−0.312)

NS

−1.21 (−0.273)

0.100

0.139

-

0.169

72

NM_001006639

Transcription elongation factor A (SII)-like 1

TCEAL1

Nucleus

1.23 (0.297)

NS

NS

0.099

0.090

-

-

73

NM_001006938

Transcription elongation factor A (SII)-like 6

TCEAL6

Unknown

1.16 (0.218)

NS

NS

0.103

0.132

-

-

74

NM_031945

Tetraspanin 10

TSPAN10

Unknown

1.35 (0.435)

NS

NS

0.149

0.215

-

-

75

NM_001080415

U2 snRNP-associated SURP domain containing

U2SURP

Nucleus

−1.17 (0.225)

NS

NS

0.105

0.196

-

-

76

NM_001167917

Ventricular zone-expressed PH domain homolog 1 (zebrafish)

VEPH1

Nucleus

1.73 (0.793)

NS

NS

0.122

0.373

-

-

77

NM_006297

X-ray repair complementing defective repair in Chinese hamster cells 1

XRCC1

Nucleus

−1.14 (−0.190)

NS

NS

0.139

0.101

-

-

78

NM_015144

Zinc finger, CCHC domain containing 14

ZCCHC14

Unknown

−1.18 (−0.235)

NS

NS

0.152

0.156

-

-

  1. NS, not significant. aRepeated genes with different sequences (number of times), fold change, technical variability, and biologic variability (between each combination of passages), represented as the mean of repeated genes sequences. For “-” listed in the biologic-variability column, the value is not provided for a given passage if significance was not found between two passages.