From: Gene markers of cellular aging in human multipotent stromal cells in culture
Number | Gene accession number | Gene name | Gene symbol | Location | Mean fold change (MFC) | Technical variability | Biologic variability (P7/P3) (P5/P3) (P7/P5) | ||
---|---|---|---|---|---|---|---|---|---|
P7/P3 (Log2(MFC)) | P5/P3 (Log2(MFC)) | P7/P5 (Log2(MFC)) | |||||||
1 | NM_003816 | ADAM metallopeptidase domain 9 | ADAM9 | Plasma membrane | 1.25 (0.321) | NS | NS | 0.112 | 0.226 |
- | |||||||||
- | |||||||||
2 | XM_005248381 | ADAM 7metallopeptidase with thrombospondin type 1 motif, 12 | ADAMTS12 | Unknown | 1.59 (0.672) | NS | NS | 0.143 | 0.477 |
- | |||||||||
- | |||||||||
3 | NM_018238 | Acylglycerol kinase | AGK | Cytoplasm | −1.10 (−0.133) | NS | −1.13 (−0.170) | 0.128 | 0.110 |
- | |||||||||
0.163 | |||||||||
4 | NM_001199183 | ATPase, Ca2 transporting, type 2C, member 1 | ATP2C1 | Cytoplasm | 1.47 (0.555) | NS | NS | 0.101 | 0.325 |
- | |||||||||
- | |||||||||
5 | NM_006886 | ATP synthase, H + transporting, mitochondrial F1 complex, epsilon subunit | ATP5E | Cytoplasm | 1.10 (0.142) | 1.10 ([0.133) | NS | 0.092 | 0.069 |
0.084 | |||||||||
- | |||||||||
6 | NM_000489 | Alpha thalassemia/mental retardation syndrome X-linked | ATRX | Nucleus | 1.18 (0.242) | NS | NS | 0.108 | 0.191 |
- | |||||||||
- | |||||||||
7 | NM_024812 | Brain and acute leukemia, cytoplasmic | BAALC | Cytoplasm | −2.33 (−1.223) | NS | NS | 0.105 | 0.509 |
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- | |||||||||
8 | NM_015379 | Brain protein I3 | BRI3 | Unknown | 1.26 (0.333) | NS | NS | 0.112 | 0.237 |
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- | |||||||||
9 | NM_004334 | Bone marrow stromal cell antigen 1 | BST1 | Plasma membrane | 2.46 (1.297) | NS | NS | 0.134 | 0.595 |
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- | |||||||||
10 | NM_001206748 | Caveolin 2 | CAV2 | Plasma membrane | 1.35 (0.438) | NS | NS | 0.207 | 0.309 |
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- | |||||||||
11 | NM_174908 | Coiled-coil domain containing 50 | CCDC50 | Cytoplasm | 1.25 (0.322) | NS | NS | 0.113 | 0.194 |
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- | |||||||||
12 | NM_003903 | Cell division cycle 16 homolog (Saccharomyces cerevisiae) | CDC16 | Nucleus | 1.16 (0.218) | NS | NS | 0.093 | 0.059 |
- | |||||||||
- | |||||||||
13 | NM_006319 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase | CDIPT | Cytoplasm | 1.27 (0.345) | NS | NS | 0.173 | 0.270 |
- | |||||||||
- | |||||||||
14 | NM_001799 | Cyclin-dependent kinase 7 | CDK7 | Nucleus | 1.21 (0.278) | NS | NS | 0.107 | 0.143 |
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- | |||||||||
15 | NM_001195132 | Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | CDKN2A | Nucleus | 1.37 (0.452) | NS | NS | 0.104 | 0.402 |
- | |||||||||
- | |||||||||
16 | NM_001854 | Collagen, type XI, alpha 1 | COL11A1 | Extracellular space | −2.19 (−1.132) | NS | NS | 0.243 | 0.947 |
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- | |||||||||
17 | NM_004370 | Collagen, type XII, alpha 1 | COL12A1 | Extracellular space | −3.00 (−1.583) | NS | NS | 0.185 | 0.895 |
- | |||||||||
- | |||||||||
18 | NM_032609 | Cytochrome c oxidase subunit IV isoform 2 (lung) | COX4I2 | Cytoplasm | −1.33 (−0.407) | NS | NS | 0.140 | 0.183 |
- | |||||||||
- | |||||||||
19 | NM_000100 | Cystatin B (stefin B) | CSTB | Cytoplasm | 1.25 (0.323) | NS | NS | 0.078 | 0.262 |
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- | |||||||||
20 | NG_021375 | Discs, large homolog 2 (Drosophila) | DLG2 | Unknown | 1.43 (0.521) | NS | NS | 0.106 | 0.263 |
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21 | NM_025219 | DNAJ (Hsp40) homolog, subfamily C, member 5 | DNAJC5 | Plasma membrane | 1.27 (0.342) | NS | NS | 0.134 | 0.289 |
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- | |||||||||
22 | NM_005740 | Dynein, axonemal, light chain 4 | DNAL4 | Cytoplasm | 1.54 (0.626) | NS | NS | 0.138 | 0.335 |
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- | |||||||||
23 | NM_001009933 | Deoxyribonuclease I-like 1 | DNASE1L1 | Cytoplasm | 1.47 (0.559) | NS | NS | 0.102 | 0.336 |
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- | |||||||||
24 | NM_033407 | Dedicator of cytokinesis 7 | DOCK7 | Plasma membrane | 1.29 (0.370) | NS | NS | 0.116 | 0.249 |
- | |||||||||
- | |||||||||
25 | NM_020390 | Eukaryotic translation initiation factor 5A2 | EIF5A2 | Cytoplasm | 1.17 (0.227) | NS | NS | 0.142 | 0.115 |
- | |||||||||
- | |||||||||
26 | NM_014568 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) | GALNT5 | Cytoplasm | 2.01 (1.005) | 1.63 (0.705) | NS | 0.074 | 0.620 |
0.216 | |||||||||
- | |||||||||
27 | NM_001523 | Hyaluronan synthase 1 | HAS1 | Plasma membrane | −1.84 (−0.882) | −1.42 (−0.507) | NS | 0.112 | 0.136 |
0.132 | |||||||||
- | |||||||||
28 | XM_005249437 | Histone cluster 1, H2ac | HIST1H2AC | Unknown | 1.99 (0.992) | NS | NS | 0.159 | 0.904 |
- | |||||||||
- | |||||||||
29 | NM_003535 | Histone cluster 1, H3j | HIST1H3J | Nucleus | −1.22 (−0.286) | NS | NS | 0.136 | 0.200 |
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- | |||||||||
30 | NM_001130688 | High-mobility group box 2 | HMGB2 | Nucleus | −1.18 (−0.239) | NS | NS | 0.082 | 0.135 |
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- | |||||||||
31 | XM_005266269 | Heterogeneous nuclear ribonucleoprotein A1-like 2 | HNRNPA1L2 | Unknown | −1.47 (−0.557) | NS | NS | 0.084 | 0.489 |
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- | |||||||||
32 | NM_004791 | Integrin, beta-like 1 (with EGF-like repeat domains) | ITGBL1 a(2) | Unknown | 1.56 (0.639) | NS | NS | 0.120 | 0.504 |
- | |||||||||
- | |||||||||
33 | NM_015167 | Jumonji domain containing 6 | JMJD6 | Plasma membrane | −1.16 (−0.220) | NS | NS | 0.100 | 0.108 |
- | |||||||||
- | |||||||||
34 | NG_028043 | Kinesin family member 16B | KIF16B | Cytoplasm | 2.04 (1.027) | 1.62 (0.697) | NS | 0.094 | 0.547 |
0.175 | |||||||||
- | |||||||||
35 | NM_001300 | Kruppel-like factor 6 | KLF6 | Nucleus | −1.43 (−0.518) | NS | NS | 0.148 | 0.086 |
- | |||||||||
36 | NM_000223 | Keratin 12 | KRT12 | Cytoplasm | 1.51 (0.598) | NS | NS | 0.234 | 0.377 |
- | |||||||||
37 | NM_199187 | Keratin 18 | KRT18 a(16) | Cytoplasm | 3.62 (1.813) | 2.34 (1.205) | NS | 0.157 | 0.891 |
0.497 | |||||||||
- | |||||||||
38 | NM_001080978 | Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 | LILRB2 | Plasma membrane | 1.11 (0.156) | NS | NS | 0.151 | 0.147 |
- | |||||||||
- | |||||||||
39 | NM_144703 | LSM14B, SCD6 homolog B (Saccharomyces cerevisiae) | LSM14B | Unknown | −1.12 (−0.165) | NS | NS | 0.116 | 0.118 |
- | |||||||||
- | |||||||||
40 | NM_020152 | MAP3K7 C-terminal like | MAP3K7CL | Unknown | 2.36 (1.238) | NS | NS | 0.13 | 0.962 |
- | |||||||||
- | |||||||||
41 | NG_013325 | Mitogen-activated protein kinase 10 | MAPK10 | Cytoplasm | −1.15 (−0.201) | −1.15 (−0.199) | NS | 0.146 | 0.172 |
0.196 | |||||||||
- | |||||||||
42 | NM_138799 | Membrane bound O-acyltransferase domain containing 2 | MBOAT2 | Cytoplasm | −1.26 (−0.338) | NS | NS | 0.105 | 0.279 |
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- | |||||||||
43 | NR_002766 | Maternally expressed 3 (nonprotein coding) | MEG3 | Unknown | 1.41 (0.505) | NS | NS | 0.218 | 0.359 |
- | |||||||||
- | |||||||||
44 | NM_001130156 | Myeloid leukemia factor 1 | MLF1 | Nucleus | −1.22 (−0.289) | −1.19 (−0.256) | NS | 0.126 | 0.126 |
0.068 | |||||||||
- | |||||||||
45 | NM_170738 | Mitochondrial ribosomal protein L11 | MRPL11 | Cytoplasm | −1.17 (−0.230) | NS | NS | 0.141 | 0.135 |
- | |||||||||
- | |||||||||
46 | NM_002489 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9 kDa | NDUFA4 | Cytoplasm | 1.25 (0.327) | NS | NS | 0.107 | 0.257 |
- | |||||||||
- | |||||||||
47 | NM_001018138 | Nonmetastatic cells 2, protein (NM23B) expressed in | NME2 | Nucleus | NS | 1.13 (0.171) | NS | 0.099 | - |
0.156 | |||||||||
- | |||||||||
48 | NM_021229 | Netrin 4 | NTN4 a(2) | Extracellular space | 2.68 (1.401) | NS | NS | 0.173 | 0.584 |
- | |||||||||
- | |||||||||
49 | NM_000436 | 3-Oxoacid CoA transferase 1 | OXCT1 | Cytoplasm | −1.29 (−0.365) | NS | NS | 0.116 | 0.312 |
- | |||||||||
- | |||||||||
50 | NM_182904 | Prolyl 4-hydroxylase, alpha polypeptide III | P4HA3 | Unknown | −1.19 (−0.250) | NS | NS | 0.080 | 0.179 |
- | |||||||||
- | |||||||||
51 | NM_006451 | Poly(A) binding protein interacting protein 1 | PAIP1 | Cytoplasm | −1.22 (−0.284) | NS | NS | 0.104 | 0.118 |
- | |||||||||
- | |||||||||
52 | NM_006197 | Pericentriolar material 1 | PCM1 | Cytoplasm | −1.20 (−0.265) | NS | NS | 0.138 | 0.172 |
- | |||||||||
- | |||||||||
53 | NM_006211 | Proenkephalin | PENK | Extracellular space | −4.15 (−2.052) | NS | NS | 0.161 | 0.915 |
- | |||||||||
- | |||||||||
54 | NM_002653 | Paired-like homeodomain 1 | PITX1 | Nucleus | −1.17 (−0.232) | NS | −1.17 (−0.236) | 0.151 | 0.209 |
- | |||||||||
0.214 | |||||||||
55 | NM_001172335 | Plastin 3 | PLS3 | Cytoplasm | 1.43 (0.515) | NS | NS | 0.136 | 0.298 |
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- | |||||||||
56 | NM_006406 | Peroxiredoxin 4 | PRDX4 | Cytoplasm | 1.23 (0.301) | NS | NS | 0.102 | 0.206 |
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- | |||||||||
57 | NM_182663 | Ras association (RalGDS/AF-6) domain family member 5 | RASSF5 | Plasma membrane | 1.93 (0.947) | NS | NS | 0.118 | 0.553 |
- | |||||||||
- | |||||||||
58 | NM_006867 | RNA-binding protein with multiple splicing | RBPMS a(2) | Unknown | 1.23 (0.298) | NS | NS | 0.111 | 0.111 |
- | |||||||||
- | |||||||||
59 | NM_006802 | Splicing factor 3a, subunit 3, 60 kDa | SF3A3 | Nucleus | −1.26 (−0.333) | NS | NS | 0.130 | 0.284 |
- | |||||||||
- | |||||||||
60 | NM_003028 | Src homology 2 domain containing adaptor protein B | SHB | Cytoplasm | 1.33 (0.407) | NS | NS | 0.118 | 0.203 |
- | |||||||||
- | |||||||||
61 | NM_001142392 | Solute carrier family 10 (sodium/bile acid cotransporter family), member 3 | SLC10A3 | Plasma membrane | 1.20 (0.261) | NS | NS | 0.184 | 0.156 |
- | |||||||||
- | |||||||||
62 | NM_005072 | Solute carrier family 12 (potassium/chloride transporters), member 4 | SLC12A4 | Plasma membrane | 1.34 (0.424) | NS | NS | 0.118 | 0.278 |
- | |||||||||
- | |||||||||
63 | NM_005073 | Solute carrier family 15 (oligopeptide transporter), member 1 | SLC15A1 | Plasma membrane | 1.17 (0.228) | NS | NS | 0.201 | 0.109 |
- | |||||||||
- | |||||||||
64 | NM_001166695 | Solute carrier family 1 (glial high-affinity glutamate transporter), member 3 | SLC1A3 | Plasma membrane | −1.72 (−0.786) | NS | NS | 0.183 | 0.352 |
- | |||||||||
- | |||||||||
65 | NM_032315 | Solute carrier family 25, member 33 | SLC25A33 | Cytoplasm | −1.12 (−0.164) | NS | NS | 0.144 | 0.139 |
- | |||||||||
- | |||||||||
66 | NM_152313 | Solute carrier family 36 (proton/amino acid symporter), member 4 | SLC36A4 | Unknown | −1.18 (−0.239) | NS | NS | 0.124 | 0.156 |
- | |||||||||
- | |||||||||
67 | NM_001013843 | SAFB-like, transcription modulator | SLTM | Nucleus | −1.15 (−0.196) | NS | NS | 0.122 | 0.146 |
- | |||||||||
- | |||||||||
68 | NM_003795 | Sorting nexin 3 | SNX3 | Cytoplasm | 1.22 (0.293) | NS | NS | 0.126 | 0.279 |
- | |||||||||
- | |||||||||
69 | NM_152343 | Spermatogenesis associated 32 | SPATA32 | Unknown | −1.17 (−0.229) | NS | NS | 0.097 | 0.153 |
- | |||||||||
- | |||||||||
70 | NM_004598 | Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | SPOCK1 | Extracellular space | 2.07 (1.052) | NS | NS | 0.148 | 0.729 |
- | |||||||||
- | |||||||||
71 | NM_001159673 | Synaptotagmin binding, cytoplasmic RNA interacting protein | SYNCRIP | Nucleus | −1.24 (−0.312) | NS | −1.21 (−0.273) | 0.100 | 0.139 |
- | |||||||||
0.169 | |||||||||
72 | NM_001006639 | Transcription elongation factor A (SII)-like 1 | TCEAL1 | Nucleus | 1.23 (0.297) | NS | NS | 0.099 | 0.090 |
- | |||||||||
- | |||||||||
73 | NM_001006938 | Transcription elongation factor A (SII)-like 6 | TCEAL6 | Unknown | 1.16 (0.218) | NS | NS | 0.103 | 0.132 |
- | |||||||||
- | |||||||||
74 | NM_031945 | Tetraspanin 10 | TSPAN10 | Unknown | 1.35 (0.435) | NS | NS | 0.149 | 0.215 |
- | |||||||||
- | |||||||||
75 | NM_001080415 | U2 snRNP-associated SURP domain containing | U2SURP | Nucleus | −1.17 (0.225) | NS | NS | 0.105 | 0.196 |
- | |||||||||
- | |||||||||
76 | NM_001167917 | Ventricular zone-expressed PH domain homolog 1 (zebrafish) | VEPH1 | Nucleus | 1.73 (0.793) | NS | NS | 0.122 | 0.373 |
- | |||||||||
- | |||||||||
77 | NM_006297 | X-ray repair complementing defective repair in Chinese hamster cells 1 | XRCC1 | Nucleus | −1.14 (−0.190) | NS | NS | 0.139 | 0.101 |
- | |||||||||
- | |||||||||
78 | NM_015144 | Zinc finger, CCHC domain containing 14 | ZCCHC14 | Unknown | −1.18 (−0.235) | NS | NS | 0.152 | 0.156 |
- | |||||||||
- |