Table 3 Ingenuity pathway analysis

Cell death and survival

1.33 × 10⁻⁴ – 4.52 × 10⁻²

15

↑ATP2C1, ↑ATRX, ↑CDK7, ↑CDKN2A, ↑DNAJC5, ↓HMGB2, ↓KLF6, ↑KRT18, ↓MAPK10, ↑NTN4, ↓PENK, ↑PRDX4, ↑RASSF5, ↓SLC1A3, ↑SPOCK1

Cellular development

8.80 × 10⁻⁴ – 4.89 × 10⁻²

21

↓AGK, ↑ATP2C1, ↑BST1, ↑CAV2, ↑CDC16, ↑CDKN2A, ↓COL11A1, ↑DOCK7, ↑EIF5A2, ↓HAS1, ↓HMGB2, ↓KLF6, ↑MEG3, ↑NME2*, ↑NTN4, ↓PCM1, ↓PENK, ↓PITX1, ↑RASSF5, ↑SLC12A4, ↓SLC1A3,

Cellular growth and proliferation

8.80 × 10⁻⁴ – 4.89 × 10⁻²

24

↓AGK, ↑CAV2, ↑CDC16, ↑CDK7, ↑CDKN2A, ↑DOCK7, ↑EIF5A2, ↓HAS1, ↓HMGB2, ↓KLF6, ↑LILRB2, ↓MAPK10, ↑MEG3, ↑NME2*, ↑NTN4, ↓PENK, ↑PRDX4, ↑RASSF5, ↓SF3A3, ↑SHB, ↑SLC12A4, ↓SLC1A3, ↑SPOCK1, ↓XRCC1

Cell cycle

1.48 × 10⁻³ – 4.52 × 10⁻²

12

↑ATRX, ↓AGK, ↑CDC16, ↑CDK7, ↑CDKN2A, ↓HAS1, ↓KLF6, ↑KRT18, ↓MLF1, ↓PCM1, ↑RASSF5, ↑SHB

Carbohydrate metabolism

3.85 × 10⁻³ – 2.82 × 10⁻²

5

↓AGK, ↑CDIPT, ↑GALNT5, ↓HAS1, ↓SLC1A3,

Function

P value

Number of genes

Genes

Respiratory system Development and function

1.48 × 10⁻³ – 1.91 × 10⁻²

3

↑CAV2, ↑CDKN2A, ↓PCM1

Skeletal and muscular system development and function

1.67 × 10⁻³ – 4.89 × 10⁻²

9

↑CAV2, ↑CDKN2A, ↓COL11A1, ↓COL12A1, ↓COX4I2, ↑DNAJC5, ↓HMGB2, ↓PITX1, ↓SYNCRIP

Tissue development

1.67 × 10⁻³ – 4.89 × 10⁻²

16

↑ADAM9, ↑ATP2C1, ↑CDKN2A, ↓COL11A1, ↓COL12A1, ↑CSTB, ↓HAS1, ↓HMGB2, ↓JMJD6, ↓KLF6, ↑KRT18, ↓MAPK10, ↑NME2*, ↑NTN4, ↓PITX1, ↓SLC1A3

Embryonic development

2.15 × 10⁻³ – 4.89 × 10⁻²

15

↑ATP2C1, ↑CDK7, ↑CDKN2A, ↓COL12A1, ↑CSTB , ↑DNAJC5, ↓HMGB2, ↓KLF6, ↑KRT18, ↑NME2*, ↑NTN4, ↓PITX1, ↑SHB, ↓SLC1A3, ↓XRCC1

Organ development

2.15 × 10⁻³ – 4.89 × 10⁻²

13

↑ADAM9, ↑ATP2C1, ↑CDKN2A, ↓COL12A1, ↑CSTB, ↑DNAJC5, ↓HMGB2, ↓KLF6, ↑KRT18, ↑NME2*, ↑NTN4, ↓PITX1, ↓SLC1A3