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Figure 3 | Stem Cell Research & Therapy

Figure 3

From: Alterations of gene expression and protein synthesis in co-cultured adipose tissue-derived stem cells and squamous cell-carcinoma cells: consequences for clinical applications

Figure 3

Effect of ADSC-SCC-co-culture on cells’ proliferative activity. (a) The growth of ADSCs on the plate significantly increased (P = 0.038) in co-culture with A431-SCCs in the transwell insert compared to mono-culture. The growth of co-cultured A431-SCCs in the transwell insert was not significantly affected (P >0.05). (b) ADSC-SCC-co-culture with A431-SCCs on the six-well plate and ADSCs in the transwell insert did not significantly affect cell growth of both cell types (P >0.05). (c) ADSC-SCC-co-culture with ADSCs on the six-well plate and pSCCs in the transwell insert significantly reduced ADSCs’ growth compared to mono-culture (P = 0.03). The proliferative activity of pSCCs in co-culture was not affected (P >0.05). (d) ADSC-SCC-co-culture with pSCCs on the six-well plate and ADSCs in the transwell insert significantly decreased the growth of pSCCs (P <0.001), that of co-cultured ADSCs was not significantly affected (P >0.05). ADSC, adipose tissue derived stem cells; SCCs, squamous cell carcinoma cells.

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