Skip to main content

Table 3 Changes in the protein expression levels of ADSCs and A431-SCCs in co-culture compared to mono-culture

From: Alterations of gene expression and protein synthesis in co-cultured adipose tissue-derived stem cells and squamous cell-carcinoma cells: consequences for clinical applications

Protein Pg/ml, ADSC mono-culture Pg/ml, A431 mono-culture Pg/ml, co-culture Fold ADSC mono-/co-culture Fold A431 mono-/co-culture
bFGF 4.7 (1.8) 7.8 (1.6) 7.5 (2.0) 1.6 - → 1.0 - →
CCL2 2,498 (821) 168 (23) 21,096 (4,041) 8.5 - ↑ 126 - ↑
CCL3 24.1 (1.4) 22.4 (1.9) 39.2 (2.9) 1.6 - → 1.7 - →
CCL4 5.8 (3.6) 2.7 (2.5) 20 (2.7) 3.5 - ↑ 7.4 - ↑
CCL5 n.d. 13 (2.5) n.d. - - → - -↓
CXCL9 n.d. n.d. 411 (24) - - ↑ - - ↑
CXCL10 4.9 (0.3) 4.6 (0.1) 6.4 (0.3) 1.3 - → 1.2 - →
Eotaxin 1.7 (0.1) 1.6 (0.3) 1.8 (0.6) 1.1 - → 1.2 - →
G-CSF 98 (19) 1,225 (135) 34,941 (4,830) 357 - ↑ 29 - ↑
GM-CSF 1.3 (0.2) 100 (8.9) 133 (28) 106 - ↑ 1.3 - →
HGF 6,892 (1,788) 34 (15) 4,049 (746) 0.6 - → 118 - ↑
IL-1b n.d. 6.1 (3.2) 11 (4.9) - - ↑ 1.8 - →
IL-2 5.6 (1.4) 5.9 (0.8) 6.2 (0.9) - - → - - →
IL-4 22 (1.3) 19 (0.7) 31 (1.8) 1.4 - → 1.6 - →
IL-6 313 (80) 45 (4.1) 13,563 (917) 43 - ↑ 301 - ↑
IL-7 20 (7.5) 33 (8.3) 100 (19) 4.9 - ↑ 3.0 - ↑
IL-8 9,213 (3,483) 3,898 (404) 49,441 (1,572) 5.4 - ↑ 13 - ↑
IL-10 7.3 (0.3) 7.8 (0.3) 16 (0.6) 2.2 - → 2.0 - →
IL-12 27.4 (8.0) 35.2 (7.8) 76 (5.1) 2.8 - ↑ 2.2 - →
IL-13 18 (1.0) 20 (1.3) 27 (1.1) 3.5 - ↑ 1.4 - →
IL-15 36 (11) 38 (19) 33 (20) 0.9 - → 0.9 - →
IL-17 11.2 (0.7) 9.6 (0.7) 14 (1.2) 1.3 - → 1.5 - →
IL-1Ra n.d. 1,084 (82) 687 (65) 0.6 - → 0.6 - →
IL-2R n.d. 109 (0.0) 50 (31) - - ↑ 0.5 - →
INF-α 84 (16) 40 (5.4) 268 (14) 118 - ↑ 6.7 - ↑
INF-γ 2.3 (0.9) 5.7 (1.4) 8.8 (2.4) 3.9 - ↑ 1.5 - →
MMP-1 33,056 (5,448) 302 (33) 43,274 (15,154) 1.3 - → 143 - ↑
MMP-3 16,089 (3,424) 72 (7) 109,950 (47,520) 6.8 - ↑ 1,527 - ↑
MMP-7 n.d. n.d. 131 (42) - - ↑ - - ↑
MMP-9 156 (18) 533 (57) 6,987 (15,036) 45 - ↑ 13 - ↑
MMP-10 357 (67) 70 (2.3) 1,202 (333) 3.4 - ↑ 17 - ↑
TNF-α 2.7 (1.3) 2.5 (1.0) 4.1 (2.0) 1.5 - → 1.7 - →
VEGF 61 (11) 132 (22) 362 (40) 6.0 - ↑ 2.8 - ↑
  1. CXCL9 and MMP-7 could only be detected in co-culture. Standard deviation is given in brackets. Results from 0 to 9.9 are shown with one decimal, results 10 or higher are displayed without decimals. n.d., not detectable; − −, not applicable.