Table 3 Changes in the protein expression levels of ADSCs and A431-SCCs in co-culture compared to mono-culture

bFGF

4.7 (1.8)

7.8 (1.6)

7.5 (2.0)

1.6 - →

1.0 - →

CCL2

2,498 (821)

168 (23)

21,096 (4,041)

8.5 - ↑

126 - ↑

CCL3

24.1 (1.4)

22.4 (1.9)

39.2 (2.9)

1.6 - →

1.7 - →

CCL4

5.8 (3.6)

2.7 (2.5)

20 (2.7)

3.5 - ↑

7.4 - ↑

CCL5

n.d.

13 (2.5)

n.d.

- - →

- -↓

CXCL9

n.d.

n.d.

411 (24)

- - ↑

- - ↑

CXCL10

4.9 (0.3)

4.6 (0.1)

6.4 (0.3)

1.3 - →

1.2 - →

Eotaxin

1.7 (0.1)

1.6 (0.3)

1.8 (0.6)

1.1 - →

1.2 - →

G-CSF

98 (19)

1,225 (135)

34,941 (4,830)

357 - ↑

29 - ↑

GM-CSF

1.3 (0.2)

100 (8.9)

133 (28)

106 - ↑

1.3 - →

HGF

6,892 (1,788)

34 (15)

4,049 (746)

0.6 - →

118 - ↑

IL-1b

n.d.

6.1 (3.2)

11 (4.9)

- - ↑

1.8 - →

IL-2

5.6 (1.4)

5.9 (0.8)

6.2 (0.9)

- - →

- - →

IL-4

22 (1.3)

19 (0.7)

31 (1.8)

1.4 - →

1.6 - →

IL-6

313 (80)

45 (4.1)

13,563 (917)

43 - ↑

301 - ↑

IL-7

20 (7.5)

33 (8.3)

100 (19)

4.9 - ↑

3.0 - ↑

IL-8

9,213 (3,483)

3,898 (404)

49,441 (1,572)

5.4 - ↑

13 - ↑

IL-10

7.3 (0.3)

7.8 (0.3)

16 (0.6)

2.2 - →

2.0 - →

IL-12

27.4 (8.0)

35.2 (7.8)

76 (5.1)

2.8 - ↑

2.2 - →

IL-13

18 (1.0)

20 (1.3)

27 (1.1)

3.5 - ↑

1.4 - →

IL-15

36 (11)

38 (19)

33 (20)

0.9 - →

0.9 - →

IL-17

11.2 (0.7)

9.6 (0.7)

14 (1.2)

1.3 - →

1.5 - →

IL-1Ra

n.d.

1,084 (82)

687 (65)

0.6 - →

0.6 - →

IL-2R

n.d.

109 (0.0)

50 (31)

- - ↑

0.5 - →

INF-α

84 (16)

40 (5.4)

268 (14)

118 - ↑

6.7 - ↑

INF-γ

2.3 (0.9)

5.7 (1.4)

8.8 (2.4)

3.9 - ↑

1.5 - →

MMP-1

33,056 (5,448)

302 (33)

43,274 (15,154)

1.3 - →

143 - ↑

MMP-3

16,089 (3,424)

72 (7)

109,950 (47,520)

6.8 - ↑

1,527 - ↑

MMP-7

n.d.

n.d.

131 (42)

- - ↑

- - ↑

MMP-9

156 (18)

533 (57)

6,987 (15,036)

45 - ↑

13 - ↑

MMP-10

357 (67)

70 (2.3)

1,202 (333)

3.4 - ↑

17 - ↑

TNF-α

2.7 (1.3)

2.5 (1.0)

4.1 (2.0)

1.5 - →

1.7 - →

VEGF

61 (11)

132 (22)

362 (40)

6.0 - ↑

2.8 - ↑