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Table 4 Changes in the protein expression levels of ADSCs and pSCCs in co-culture compared to mono-culture

From: Alterations of gene expression and protein synthesis in co-cultured adipose tissue-derived stem cells and squamous cell-carcinoma cells: consequences for clinical applications

Protein

Pg/ml, ADSC mono-culture

Pg/ml, pSCC mono-culture

Pg/ml, co-culture

Fold ADSC mono-/co-culture

Fold pSCC mono-/co-culture

bFGF

3.9 (1.9)

5.3 (1.1)

6.6 (1.8)

1.7 - →

1.3 - ↑

CCL2

2,768 (109)

565 (83)

5,707

2.1 - →

10 - ↑

CCL3

26 (1.7)

25 (1.5)

32 (4.6)

1.2 - →

1.3 - →

CCL4

2.9 (2.0)

2.0 (0.0)

11 (4.9)

3.8 - ↑

5.4 - ↑

CCL5

n.d.

216 (32)

95 (8.4)

- - ↑

0.4 - →

CXCL9

n.d.

n.d.

208 (14)

- - ↑

- - ↑

CXCL10

4.7 (0.2)

5.7 (0.5)

7.0 (0.8)

1.5 - →

1.2 - →

Eotaxin

1.7 (0.4)

1.8 (0.3)

2.1 (0.2)

1.3 - →

1.2 - →

GM-CSF

1.0 (0.1)

13 (0.9)

32 (4.6)

10 - ↑

0.8 - →

G-CSF

40 (23)

n.d.

3,076 (330)

77 - ↑

- - ↑

HGF

6,125 (317)

72 (31)

3,661 (174)

0.6 - →

51 - ↑

IL-1b

n.d.

n.d.

6.2 (1.2)

- - ↑

- - ↑

IL-2

4.7 (0.7)

5.4 (0.6)

5.2 (0.9)

2.5 - ↑

1.0 - →

IL-4

22 (0.9)

21 (0.6)

29 (2.1)

1.3 - →

1.4 - →

IL-6

349 (40)

4.0 (1.4)

1,912 (396)

5.5 - ↑

480 - ↑

IL-7

16 (1.2)

n.d.

53 (23)

3.4 - ↑

- - ↑

IL-8

11,219 (652)

8,825 (791)

34,032 (1,805)

3.0 - ↑

3.9 - ↑

IL-10

7.3 (0.0)

6.4 (0.6)

9.5 (0.7)

1.3 - →

1.5 - →

IL-12

28 (5.1)

29 (6.0)

54 (11)

1.9 - →

1.9 - →

IL-13

18 (1.6)

15 (0.8)

20 (3.0)

1.1 - →

1.4 - →

IL-17

11 (1.1)

10 (0.6)

14 (1.4)

1.3 - →

1.4 - →

INF-α

102 (5.6)

61 (6.6)

156 (12)

1.5 - →

2.6 - ↑

INF-γ

2.2 (0.5)

3.0 (1.4)

6.1 (3.5)

1.6 - →

1.0 - →

MMP-1

44,830 (2,372)

n.d.

24,473 (1,564)

1.8 - →

- - ↑

MMP-3

2,288 (268)

47 (2.6)

4,354 (386)

1.9 - →

92 - ↑

MMP-9

110 (5.2)

275 (19)

174 (11)

1.6 - →

1.6 - →

MMP-10

149 (14)

17 (3.5)

248 (13)

1.7 - →

14 - ↑

TNF-α

2.1 (0.5)

3.2 (0.9)

3.2 (1.9)

1.6 - →

1.0 - →

VEGF

63 (8.7)

26 (8.1)

117 (30)

1.9 - →

4.6 - ↑

  1. CXCL9 and IL-1β could only be detected in co-culture. Standard deviation is given in brackets. Results from 0 to 9.9 are shown with one decimal, results 10 or higher are displayed without decimals. n.d., not detectable, − −, not applicable.