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Table 4 Changes in the protein expression levels of ADSCs and pSCCs in co-culture compared to mono-culture

From: Alterations of gene expression and protein synthesis in co-cultured adipose tissue-derived stem cells and squamous cell-carcinoma cells: consequences for clinical applications

Protein Pg/ml, ADSC mono-culture Pg/ml, pSCC mono-culture Pg/ml, co-culture Fold ADSC mono-/co-culture Fold pSCC mono-/co-culture
bFGF 3.9 (1.9) 5.3 (1.1) 6.6 (1.8) 1.7 - → 1.3 - ↑
CCL2 2,768 (109) 565 (83) 5,707 2.1 - → 10 - ↑
CCL3 26 (1.7) 25 (1.5) 32 (4.6) 1.2 - → 1.3 - →
CCL4 2.9 (2.0) 2.0 (0.0) 11 (4.9) 3.8 - ↑ 5.4 - ↑
CCL5 n.d. 216 (32) 95 (8.4) - - ↑ 0.4 - →
CXCL9 n.d. n.d. 208 (14) - - ↑ - - ↑
CXCL10 4.7 (0.2) 5.7 (0.5) 7.0 (0.8) 1.5 - → 1.2 - →
Eotaxin 1.7 (0.4) 1.8 (0.3) 2.1 (0.2) 1.3 - → 1.2 - →
GM-CSF 1.0 (0.1) 13 (0.9) 32 (4.6) 10 - ↑ 0.8 - →
G-CSF 40 (23) n.d. 3,076 (330) 77 - ↑ - - ↑
HGF 6,125 (317) 72 (31) 3,661 (174) 0.6 - → 51 - ↑
IL-1b n.d. n.d. 6.2 (1.2) - - ↑ - - ↑
IL-2 4.7 (0.7) 5.4 (0.6) 5.2 (0.9) 2.5 - ↑ 1.0 - →
IL-4 22 (0.9) 21 (0.6) 29 (2.1) 1.3 - → 1.4 - →
IL-6 349 (40) 4.0 (1.4) 1,912 (396) 5.5 - ↑ 480 - ↑
IL-7 16 (1.2) n.d. 53 (23) 3.4 - ↑ - - ↑
IL-8 11,219 (652) 8,825 (791) 34,032 (1,805) 3.0 - ↑ 3.9 - ↑
IL-10 7.3 (0.0) 6.4 (0.6) 9.5 (0.7) 1.3 - → 1.5 - →
IL-12 28 (5.1) 29 (6.0) 54 (11) 1.9 - → 1.9 - →
IL-13 18 (1.6) 15 (0.8) 20 (3.0) 1.1 - → 1.4 - →
IL-17 11 (1.1) 10 (0.6) 14 (1.4) 1.3 - → 1.4 - →
INF-α 102 (5.6) 61 (6.6) 156 (12) 1.5 - → 2.6 - ↑
INF-γ 2.2 (0.5) 3.0 (1.4) 6.1 (3.5) 1.6 - → 1.0 - →
MMP-1 44,830 (2,372) n.d. 24,473 (1,564) 1.8 - → - - ↑
MMP-3 2,288 (268) 47 (2.6) 4,354 (386) 1.9 - → 92 - ↑
MMP-9 110 (5.2) 275 (19) 174 (11) 1.6 - → 1.6 - →
MMP-10 149 (14) 17 (3.5) 248 (13) 1.7 - → 14 - ↑
TNF-α 2.1 (0.5) 3.2 (0.9) 3.2 (1.9) 1.6 - → 1.0 - →
VEGF 63 (8.7) 26 (8.1) 117 (30) 1.9 - → 4.6 - ↑
  1. CXCL9 and IL-1β could only be detected in co-culture. Standard deviation is given in brackets. Results from 0 to 9.9 are shown with one decimal, results 10 or higher are displayed without decimals. n.d., not detectable, − −, not applicable.