Figure 7

Effects of xenograft with islet-like cell clusters on the recovery of streptozocin-induced diabetic mice. In the nonadherent induction group, the blood glucose levels of 10 diabetic mice fell to normal within 2 weeks following the transplantation, but three of the 10 mice regained hyperglycemia when their xenograft was removed 28 days post transplantation and all died within 45 days after the removal; the remaining seven mice without the removal of xenograft maintained normal levels of blood glucose for at least 80 days (A) and gained body weight slightly (B). The intraperitoneal glucose tolerance test indicated that the islet-like cell clusters had a normal glucose clearance rate after transplantation, but were not as effective as native pancreatic beta-cells (C). The effects of xenograft in the adherent induction group are similar to those in the nonadherent induction group. In the non-induction control group, six diabetic mice maintained high blood glucose levels (>18 mmol/l) after bone marrow mesenchymal stem cell of human first-trimester abortus transplantation, lost their body weight continuously and died within 45 days after the transplantation, and so did the mice with removal of their testes 28 days post transplantation.