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Figure 5 | Stem Cell Research & Therapy

Figure 5

From: Lipopolysaccharide differentially affects the osteogenic differentiation of periodontal ligament stem cells and bone marrow mesenchymal stem cells through Toll-like receptor 4 mediated nuclear factor κB pathway

Figure 5

Blockage of the TLR4 or NF-κB pathway effectively reduces the bone loss caused by LPS in vivo . (A) Bone loss in the saline group, LPS group, LPS + anti-TLR4 group and LPS + PDTC group. (B) Alveolar bone loss determination of maxillary molars. Seventeen sites per quadrant (three sites for each of five roots and one site for each root furcation of two teeth) were analyzed morphometrically. (C) Mean alveolar bone loss. Data represent the means ± SD. *P <0.05 (n = 3). LPS, lipopolysaccharide; NF-κB, nuclear factor- κB; PDTC, pyrrolidinedithiocarbamate; SD, standard deviation; TLR4, Toll-like receptor 4.

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Stem Cell Research & Therapy

ISSN: 1757-6512