Table 2 Estimation of infertility risk using different types of cytotoxic treatments

Any alkylating agent plus total body irradiation, pelvic radiation, or testicular radiation (for example, procarbazine, nitrogen mustard, cyclophosphamide)

BEP × 2–4 cycles (bleomycin, etoposide, cisplatin)

ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine)

Radioactive iodine

Busulfan (≥600 mg/m²)

Carboplatin cumulative dose ≤2 g/m²

CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone)

Testicular radiation dose (<0.2 Gy)

Busulfan/cyclophosphamide

Cisplatin cumulative dose <400 mg/m²

COP (cyclophosphamide, vincristine, prednisone)

CBV (cyclophosphamide, BCNU, etoposide), BCNU cumulative dose ≥300 mg/m²

Testicular radiation dose (scatter from abdominal/pelvic radiation) (1–6 Gy)

NOVP (mitoxantrone, vincristine, vinblastine, prednisone)

ChIVPP (chlorambucil, vinblastine, prednisone, procarbazine)

OEPA × 2 cycles (vincristine, etoposide, prednisone, doxorubicin)

ChIVPP/EVA (chlorambucil, vinblastine, prednisone, procarbazine, doxorubicin, vincristine, etoposide)

Testicular radiation dose (0.2-0.7 Gy)

COPP × 6 cycles (cyclophosphamide, vincristine, procarbazine, prednisone)

COPP/ABVD (cyclophosphamide, vincristine, procarabazine, prednisone, doxorubicin, bleomycin, vinblastine, dacarbazine)

Cranial/brain radiation ≥40 Gy

Cyclophosphamide >7.5 g/m²

Cyclophosphamide as bone marrow transplant conditioning

Cyclophosphamide (19 g/m²) plus total body irradiation

MOPP > 3 cycles (nitrogen mustard, vincristine, procarabazine, prednisone)

MOPP/ABVD (nitrogen mustard, vincristine, procarabazine, prednisone, doxorubicin, bleomycin, vinblastine, dacarbazine)

MVPP (nitrogen mustard, vinblastine, prednisone, procarabzine)

Procarbazine cumulative dose ≥4 g/m²

Testicular radiation dose >2.5 Gy in adults

Testicular radiation dose ≥6 Gy in children

Total body irradiation