Figure 1
From: Developing neural stem cell-based treatments for neurodegenerative diseases
Developing the neural stem cell-based approach for treating Alzheimer’s disease. The concept of using human induced pluripotent stem cells (iPSCs) and their neural stem cell (NSC) derivatives, alongside safe-harbor targeted genetic engineering, to develop a personalized cellular therapy for Alzheimer’s disease. Clinically relevant human iPSCs (passage 7) were derived from skin punch biopsies, differentiated into NSCs, and (as shown on the right) stained Pax6 (green), Sox1 (red) and DAPI (blue). The figure is based on unpublished data of Kaitlin Ingraham, Patricia Phelps, and James Byrne. See JA Byrne, unpublished data, 2014 and [10].