Figure 2
From: Substrate and strain alter the muscle-derived mesenchymal stem cell secretome to promote myogenesis
Muscle-derived mesenchymal stem/stromal cell (mMSC) growth and inflammatory factor gene expression. mMSCs were plated on laminin (LAM) or collagen (COL) and were either exposed to mechanical strain or remained unstrained. mRNA for vascular endothelial growth factor a (VEGFa) (A), granulocyte-macrophage colony-stimulating factor (GM-CSF) (B), hepatocyte growth factor (HGF) (C), interleukin-6 (IL-6) (D), transforming growth factor-beta 1 (TGF-β1) (E), and tumor necrosis factor-alpha (TNF-α) (F) was analyzed 3 hours after strain and expressed relative to LAM no strain (n = 3 per group). Data are presented as mean ± standard error of the mean. *P <0.05; **P <0.01 versus LAM.