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Figure 1 | Stem Cell Research & Therapy

Figure 1

From: MicroRNA-363 negatively regulates the left ventricular determining transcription factor HAND1 in human embryonic stem cell-derived cardiomyocytes

Figure 1

hESC differentiation into cardiomyocytes identifies developmentally regulated miRNAs. (A) Cardiac progenitors (Day 8) and embryonic CMs (Day 14) were compared for miRNA expression and represented as log2 fold-change (false discovery rate, FDR, <0.05) of relative miRNA expression compared with undifferentiated cells. (B) Venn diagram illustrating miRNAs that were differentially expressed over a 14-day hESC differentiation protocol. Note that the centroid representing undifferentiated versus Day 8 and/or Day 14 analyses contains the miRNAs speculated to target left and right ventricular-specifying transcription factors.

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Stem Cell Research & Therapy

ISSN: 1757-6512