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Figure 8 | Stem Cell Research & Therapy

Figure 8

From: MicroRNA-363 negatively regulates the left ventricular determining transcription factor HAND1 in human embryonic stem cell-derived cardiomyocytes

Figure 8

Cardiac cell fate with anti-miR-363 treatment. hESCs were differentiated in the presence of anti-miR-363, and beating clusters were microdissected and analyzed with qPCR. (A) HAND1-enriched CMs were produced with miR-363 inhibition. Data shown are mean ± SEM (n = 3); *P < 0.05. (B) Schematic representation of miR-363 function. miR-363 regulates HAND1 expression, independent of NKX2.5, leading to left ventricular CM-subtype specification.

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Stem Cell Research & Therapy

ISSN: 1757-6512