Figure 5

Biomechanical properties. Biomechanical properties of the newly formed extracellular matrix at day 28 of bone marrow-derived stem cells (BMSCs), mixed cultures, or chondrocytes co- and tri-cultured with osteoarthritis cartilage (FC) were analyzed and calculated in relation to monocultured controls (dotted lines at 100% represent monoculture values). Young’s modulus of (A) 0% to 10% and (B) 40% to 50% strain was determined by using unconfined compression. Aggregate modulus at equilibrium (C) and hydraulic permeability (D) were determined by using confined compression performed at 50% compressive strain. Ch, chondrocytes.