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Figure 1 | Stem Cell Research & Therapy

Figure 1

From: Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectives

Figure 1

Schematic representation of the role of morphogens during neural tube formation in vivo . Color gradients are indicative of the expression levels of each morphogen. Bone morphogen protein (BMP) can be found in high concentrations in the dorsal part of the neural tube (light green): its levels decrease along the ventral part. In contrast, Sonic hedgehog (Shh) is more concentrated in the ventral part (orange), but it is not expressed in the dorsal one. Fibroblast growth factor (FGF) is highly expressed in the anterior (purple) and posterior (dark green) parts of the neural tube. Retinoic acid (RA) levels of expression decrease in the posterior part (light blue), where high concentrations of both FGF and Wnt can be found. MN, motor neuron.

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Stem Cell Research & Therapy

ISSN: 1757-6512