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Table 3 Repair of injured rat spinal cord using biomaterial scaffolds and mesenchymal stem cells

From: Repair of injured spinal cord using biomaterial scaffolds and stem cells

Injury

SCI Stage

Scaffold

Outcome

Reference

Complete transection (T10)

Acute

PLGA multichannel conduits

Cells integrated well into host tissue

[76]

Complete transection (T8-T9)

Acute

PLGA porous scaffolds and small intestine submucosa

Significant improvement in functional outcomes, improved greater axon regeneration

[59]

Transection (T10-11)

Acute

Gelatin sponge

Reduced inflammatory response and cavity formation, promotion of angiogenesis

[20]

Balloon-induced compression (T8-T9)

Implantation of scaffolds with cells 5 weeks after original injury

HPMA-RGD hydrogel

Significant improvement

[58]

  1. HPMA-RGD, N-(2-hydroxypropyl)-methacrylamide with attached amino acid sequence Arg-Gly-Asp; PLGA, poly(lactic-co-glycolic acid).