From: Repair of injured spinal cord using biomaterial scaffolds and stem cells
Injury | SCI Stage | Scaffold | Outcome | Reference |
---|---|---|---|---|
Complete transection (T10) | Acute | PLGA multichannel conduits | Cells integrated well into host tissue | [76] |
Complete transection (T8-T9) | Acute | PLGA porous scaffolds and small intestine submucosa | Significant improvement in functional outcomes, improved greater axon regeneration | [59] |
Transection (T10-11) | Acute | Gelatin sponge | Reduced inflammatory response and cavity formation, promotion of angiogenesis | [20] |
Balloon-induced compression (T8-T9) | Implantation of scaffolds with cells 5Â weeks after original injury | HPMA-RGD hydrogel | Significant improvement | [58] |