Macrophage cell cycle arrest induction by orbital fat-derived stem cells. (A) Condition medium of orbital fat-derived stem cells (OFSCs-CM) reduced the viability of macrophages (MØ) at OFSC/MØ ratio of 2 and higher. (B) Both OFSCs-CM and co-culture with OFSCs increased the G0/G1 population of macrophages. (C) OFSCs-CM reduced cyclin D1, CDK4, and CDK6 and increased p21cip1 and p27kip1 in MØ. t test, *P < 0.05, n = 3. LPS, lipopolysaccharide.