Paracrine effect of orbital fat-derived stem cells attenuating proinflammatory ability of macrophages. (A) Neither lipopolysaccharide (LPS) nor condition medium (CM) of orbital fat-derived stem cells (OFSCs) altered interferon gamma (IFNγ) expression in macrophages. OFSCs-CM inhibited LPS-induced tumor necrosis factor alpha (TNFα) (B), interleukin (IL)-1α (D) and IL-1β (E) expression in macrophages. Analysis of variance with Tukey’s post hoc test, different characteristics represented different level of significance at 95% confidence interval, n = 3. OFSCs-CM reduced LPS-induced TNFα (C) and IL-1β (F) production in macrophages.