Figure 2

Assessment of cardiac function in infarcted mouse hearts transplanted with chorionic plate mesenchymal stem cells (cp-MSCs) or placebo. Echocardiography was performed before (corresponding to day -22 of treatment) and 20 days after myocardial infarction (corresponding to day -1 of treatment) to obtain baseline values in mice receiving cp-MSCs (squares) or placebo (triangles). Analysis of (A) ejection fraction, (B) end-diastolic volume, and (C) end-systolic volume was performed every 7 days after each cell or placebo injection. Day 7 corresponds to 7 days after the first injection, day 15 corresponds to 7 days after the second injection, and day 23 corresponds to 7 days after the third injection. Animals were followed up to 39 days after the first injection. *P <0.05 and **P <0.01 when comparing cp-MSC with placebo group at each time point. Sham-operated mice (circles), which did not undergo left anterior descending coronary artery occlusion, are shown as controls to indicate normal values for each parameter.