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Figure 3 | Stem Cell Research & Therapy

Figure 3

From: Improvement of cardiac function by placenta-derived mesenchymal stem cells does not require permanent engraftment and is independent of the insulin signaling pathway

Figure 3

In vivo imaging of transduced chorionic plate mesenchymal stem cell (cp-MSCs) administered by intramyocardial injection in sham and infarcted mice. Bioluminescence imaging was repeated daily. After the first injection, the signal was located in a region anatomically compatible with the heart in sham (A) and infarcted (B) mice injected with cp-MSCs. After the second and third injections, the luminescent signal was observed for only 1 or 2 days in these animals. In addition, the signal intensity was lower than after the first injection. The scales represent luminescence intensity in radiance units, in which red and blue are the most and least intense, respectively. (C) Signal quantification in sham (circles) and infarcted (squares) groups after the first injection of cp-MSCs. Quantification of the bioluminescent signal showed no statistical difference in the engraftment period for both groups.

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